Edible Mushrooms and Beta-Glucans: Impact on Human Health.
Edible Mushrooms and Beta-Glucans: Impact on Human Health.
复制标题
DOI：
10.3390/nu13072195
复制
发表时间：
2021-06-25
期刊：
影响因子：
5.9
通讯作者：
Iacoviello L
中科院分区：
文献类型：
--
作者：
Cerletti C;Esposito S;Iacoviello L
蘑菇细胞壁富含β-葡聚糖，这是葡萄糖亚基的长链或短链聚合物，具有β-1,3和β-1,6键，分别负责线性和分支结构。不同谷物中的β-葡聚糖不具有1,6键和分支结构。利用纯化的β-葡聚糖或真菌提取物在细胞和实验模型上描述了蘑菇的免疫调节和抗炎作用；它们的潜在临床应用已经在不同的情况下进行了测试，例如呼吸道复发感染或大手术并发症。β-葡聚糖的另一个有前景的应用是在癌症上，作为常规化疗的辅助。β-葡聚糖可以保护心血管系统，改善葡萄糖、脂质代谢和血压：燕麦和大麦β-葡聚糖中观察到的这些活性，需要在蘑菇β-葡聚糖的人体研究中得到证实。另一方面，蘑菇也可以通过许多其他成分保护心血管系统，如生物活性酚类化合物、维生素和矿物质元素。关于蘑菇的机制和健康益处的知识不断增长，鼓励了β-葡聚糖潜在临床应用的发展，也进一步证明了它们在健康生活方式中保持健康和预防疾病的作用。
Mushroom cell walls are rich in β-glucans, long or short-chain polymers of glucose subunits with β-1,3 and β-1,6 linkages, that are responsible for the linear and branching structures, respectively. β-glucans from cereals, at variance, have no 1,6 linkages nor branching structures. Both immunomodulatory and anti-inflammatory effects of mushrooms have been described using purified β-glucans or fungi extracts on cellular and experimental models; their potential clinical use has been tested in different conditions, such as recurrent infections of the respiratory tract or complications of major surgery. Another promising application of β-glucans is on cancer, as adjuvant of conventional chemotherapy. β-glucans may protect the cardiovascular system, ameliorating glucose, lipid metabolism, and blood pressure: these activities, observed for oat and barley β-glucans, require confirmation in human studies with mushroom β-glucans. On the other hand, mushrooms may also protect the cardiovascular system via a number of other components, such as bioactive phenolic compounds, vitamins, and mineral elements. The growing knowledge on the mechanism(s) and health benefits of mushrooms is encouraging the development of a potential clinical use of β-glucans, and also to further document their role in preserving health and prevent disease in the context of healthy lifestyles.
登录
查看更多内容
影响因子：
5.6
作者：
Jesenak, Milos;Majtan, Juraj;Hrubisko, Martin
通讯作者：
Hrubisko, Martin
影响因子：
6.1
作者：
Caz, Victor;Gil-Ramirez, Alicia;Soler-Rivas, Cristina
通讯作者：
Soler-Rivas, Cristina
影响因子：
2.9
作者：
Basso, A. M. M.;De Castro, R. J. A.;Bocca, A. L.
通讯作者：
Bocca, A. L.
影响因子：
3.7
作者：
Johnson, E.;Forland, D. T.;Hetland, G.
通讯作者：
Hetland, G.
影响因子：
5.2
作者：
De Marco Castro E;Calder PC;Roche HM
通讯作者：
Roche HM