Prenatal stress or high-fat diet increases susceptibility to diet-induced obesity in rat offspring.
Prenatal stress or high-fat diet increases susceptibility to diet-induced obesity in rat offspring.
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作者：
Tamashiro KL;Terrillion CE;Hyun J;Koenig JI;Moran TH
产前环境的干扰与成人慢性疾病的发展有关，这一发现引发了“巴克假说”或“成人疾病的发育起源”概念。在这项研究中，我们使用动物模型来确定母亲产前压力和高脂肪喂养对发育中的后代的代谢影响。怀孕雌性 Sprague-Dawley 大鼠在整个妊娠期和哺乳期维持标准饲料或 60% 高脂肪饮食。每组中的一半在妊娠第三周期间暴露于新的可变应激模式，而对照母鼠则不受干扰。测量后代直至成年早期的体重、身体成分、葡萄糖耐量和内分泌参数。与标准饲料对照幼崽相比，经历过产前应激和/或高脂肪饮食的母鼠的雄性和雌性幼崽在出生后第 7 天开始体重更重。断奶时摄入高脂肪饮食会增加成年早期的体重效应，并导致更多的肥胖。断奶后采用标准饲料的幼崽在葡萄糖清除率或胰岛素分泌方面没有显着差异。然而，如果母鼠吃高脂肪饮食、经历产前压力或两者兼而有之，断奶后吃高脂肪饮食的幼崽就会出现葡萄糖耐量受损的情况。我们的数据表明，宫内或产后环境中的产前压力和/或高脂肪饮食会影响后代，增加他们对饮食引起的肥胖的易感性，并导致继发性不良代谢后果。
Perturbations to the prenatal environment have been associated with the development of adult chronic disease, findings that gave rise to the “Barker Hypothesis” or the “developmental origins of adult disease” concept. In this study, we used an animal model to determine the metabolic consequences of maternal prenatal stress and high-fat feeding on the developing offspring. Pregnant female Sprague-Dawley rats were maintained on standard chow or 60% high-fat diet throughout gestation and lactation. Half of each group were exposed to a novel variable stress paradigm during the 3rd week of gestation, whereas control dams were left undisturbed. Body weight, body composition, glucose tolerance, and endocrine parameters were measured in offspring through early adulthood. Male and female pups from dams that experienced prenatal stress and/or were on a high-fat diet weighed more beginning on postnatal day 7 compared with standard chow–control pups. Access to high-fat diet at weaning increased the body weight effect through early adulthood and was attributable to greater adiposity. Pups weaned onto standard chow diet showed no significant difference in glucose clearance or insulin secretion. However, pups weaned onto high-fat diet had impaired glucose tolerance if their dams were on a high-fat diet, experienced prenatal stress, or both. Our data demonstrate that prenatal stress and/or high-fat diet during the intrauterine or postnatal environment affects offspring in a manner that increases their susceptibility to diet-induced obesity and leads to secondary adverse metabolic consequences.
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影响因子：
120.7
作者：
Flegal, KM;Carroll, MD;Johnson, CL
通讯作者：
Johnson, CL
影响因子：
4.2
作者：
Fahrenkrog, S;Harder, T;Plagemann, A
通讯作者：
Plagemann, A
DOI：
10.1016/0165-3806(95)00078-r
发表时间：
1995-09-29
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
JONES, AP;POTHOS, EN;HOEBEL, BG
通讯作者：
HOEBEL, BG
DOI：
10.1016/s0889-8529(05)70099-2
发表时间：
1999-12-01
影响因子：
4.5
作者：
Caprio, S;Tamborlane, WV
通讯作者：
Tamborlane, WV
影响因子：
3.2
作者：
Jebb, SA;Rennie, KL;Cole, TJ
通讯作者：
Cole, TJ