Self-Reported Visual Perceptual Abnormalities Are Strongly Associated with Core Clinical Features in Psychotic Disorders.
Self-Reported Visual Perceptual Abnormalities Are Strongly Associated with Core Clinical Features in Psychotic Disorders.
复制标题
DOI：
10.3389/fpsyt.2018.00069
复制
发表时间：
2018
影响因子：
4.7
通讯作者：
Silverstein SM
中科院分区：
文献类型：
--
作者：
Keane BP;Cruz LN;Paterno D;Silverstein SM
过去使用波恩基本症状评估量表（以下简称波恩量表）的研究表明，自我报告的知觉/认知障碍揭示了哪些人患有或即将患上精神分裂症。在这里，我们特别关注自我报告的视觉感知异常（VPAs）的临床价值，因为它们尚未得到充分研究，并且与自杀意念，阴性症状和客观视觉功能障碍有关。使用17个波恩量表视力项目，我们横断面调查了21例首发精神病和22例慢性精神分裂症/情感性精神障碍（SZ/SA）患者的VPAs终生发生率。探讨了VPA与病程、症状严重程度、当前功能、病前功能、诊断和发病年龄之间的关系。VPA增加与以下因素相关：发病年龄较早;更多的妄想、幻觉、怪异行为和抑郁症状;以及病前社会功能较差，尤其是在儿童和青少年早期。SZ/SA参与者赞同更多的VPAs相比，精神分裂症或精神病性障碍NOS，特别是在感知颜色，身体，面孔，物体运动，和双重/反向的视觉。首发和慢性患者自我报告的VPA的范围惊人地相似，并且不依赖于抗精神病药物的类型或数量。作为一个比较基准，一生中幻视的发生并不取决于诊断，只与病前社会功能差有关。一个简短的17个项目的采访来自波恩量表与精神分裂症的核心临床特征密切相关。VPA有望用于阐明诊断、预测结果和指导神经认知研究。
Past studies using the Bonn Scale for the Assessment of Basic Symptoms (hereafter, Bonn Scale) have shown that self-reported perceptual/cognitive disturbances reveal which persons have or will soon develop schizophrenia. Here, we focused specifically on the clinical value of self-reported visual perceptual abnormalities (VPAs) since they are underexplored and have been associated with suicidal ideation, negative symptoms, and objective visual dysfunction. Using the 17 Bonn Scale vision items, we cross-sectionally investigated lifetime occurrence of VPAs in 21 first-episode psychosis and 22 chronic schizophrenia/schizoaffective disorder (SZ/SA) patients. Relationships were probed between VPAs and illness duration, symptom severity, current functioning, premorbid functioning, diagnosis, and age of onset. Increased VPAs were associated with: earlier age of onset; more delusions, hallucinations, bizarre behavior, and depressive symptoms; and worse premorbid social functioning, especially in the childhood and early adolescent phases. SZ/SA participants endorsed more VPAs as compared to those with schizophreniform or psychotic disorder-NOS, especially in the perception of color, bodies, faces, object movement, and double/reversed vision. The range of self-reported VPAs was strikingly similar between first-episode and chronic patients and did not depend on the type or amount of antipsychotic medication. As a comparative benchmark, lifetime occurrence of visual hallucinations did not depend on diagnosis and was linked only to poor premorbid social functioning. A brief 17-item interview derived from the Bonn Scale is strongly associated with core clinical features in schizophrenia. VPAs hold promise for clarifying diagnosis, predicting outcome, and guiding neurocognitive investigations.
登录
查看更多内容
影响因子：
3.7
作者：
Kim J;Park S;Blake R
通讯作者：
Blake R
影响因子：
2.9
作者：
Mathalon, Daniel H.;Ford, Judith M.
通讯作者：
Ford, Judith M.
影响因子：
4.5
作者：
Meng, Heiner;Schimmelmann, Benno Graf;Resch, Franz
通讯作者：
Resch, Franz
影响因子：
6.6
作者：
Jaeger, J;Berns, SM;Czobor, P
通讯作者：
Czobor, P
影响因子：
--
作者：
Klosterkötter, J;Hellmich, M;Schultze-Lutter, F
通讯作者：
Schultze-Lutter, F