Neural pathways from the central nucleus of the amygdala to the paraventricular nucleus of the hypothalamus are involved in induction of yawning behavior due to emotional stress in rats
Neural pathways from the central nucleus of the amygdala to the paraventricular nucleus of the hypothalamus are involved in induction of yawning behavior due to emotional stress in rats
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从杏仁核中央核到下丘脑室旁核的神经通路参与诱导大鼠情绪应激引起的打哈欠行为
DOI：
10.1016/j.bbr.2022.114091
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发表时间：
2023
影响因子：
2.7
通讯作者：
Kita I
中科院分区：
文献类型：
--
作者：
Kubota N;Amemiya S;Yanagita S;Kita I
由于打哈欠通常是在紧张或焦虑等压力或情绪化的情况下观察到的，这表明打哈欠可以被认为是一种情绪行为。然而，情绪诱导打哈欠的神经机制仍不清楚。众所周知，下丘脑室旁核（PVN）是诱导打哈欠行为最重要的脑结构。我们以前的研究表明，打哈欠的诱导涉及杏仁核中央核（CeA），以及PVN。因此，情绪诱导的哈欠可能是通过激活从CeA到PVN的直接/间接神经通路诱导的。我们目前的研究采用了逆行追踪（注射荧光金（FG）到PVN）和c-Fos免疫组织化学的组合，以检查引起情绪诱导的打哈欠的神经通路。我们还进行了病变实验上的CeA使用鹅膏蕈氨酸，神经毒素，以确定是否CeA参与诱导情绪诱导打哈欠。恐惧条件反射引起的情绪应激诱导了哈欠行为，并诱导终纹床核（BNST）中c-Fos和FG双标记细胞的表达，但不在CeA中。此外，鹅膏蕈氨酸引起的CeA病变取消了情绪诱导的哈欠的诱导。这些结果表明，从CeA到PVN通过BNST的神经通路可能主要参与情绪诱导的哈欠行为的诱导。
As yawning is often observed in stressful or emotional situations such as tension and anxiety, this suggests that yawning can be considered to be an emotional behavior. However, the neural mechanisms underlying emotion-induced yawning remain unclear. It is well known that the hypothalamic paraventricular nucleus (PVN) is the most important brain structure for induction of yawning behavior. We previously showed that induction of yawning involves the central nucleus of the amygdala (CeA), as well as the PVN. Therefore, emotion-induced yawning could potentially be induced through activation of the direct/indirect neural pathways from the CeA to the PVN. Our present study used a combination of retrograde tracing (injection of Fluoro-Gold (FG) into the PVN) and c-Fos immunohistochemistry to examine the neural pathways that evoke emotion-induced yawning. We additionally performed lesion experiments on the CeA using ibotenic acid, a neurotoxin, to determine whether the CeA is involved in the induction of emotion-induced yawning. Emotional stress by fear conditioning induced yawning behavior, and induced expression of double-labeled cells for c-Fos and FG in the bed nucleus of the stria terminalis (BNST), but not in the CeA. Furthermore, the CeA lesions caused by ibotenic acid abolished the induction of emotion-induced yawning. These results suggest that a neural pathway from the CeA to the PVN via the BNST may be primarily involved in the induction of emotion-induced yawning behavior.
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影响因子：
2.9
作者：
Kita, I;Yoshida, Y;Nishino, S
通讯作者：
Nishino, S
大鼠室旁核的电和化学刺激引起的刻板打哈欠反应。
影响因子：
2.5
作者：
I. Sato;Ichiro Kita;M. Oguri;H. Arita
通讯作者：
H. Arita
DOI：
10.1111/j.1749-6632.1993.tb49929.x
发表时间：
1993-01-01
期刊：
CORTICOTROPIN-RELEASING FACTOR AND CYTOKINES: ROLE IN THE STRESS RESPONSE
影响因子：
--
作者：
MENZAGHI, F;HEINRICHS, SC;KOOB, GF
通讯作者：
KOOB, GF
影响因子：
1.9
作者：
Waddell, J;Morris, RW;Bouton, ME
通讯作者：
Bouton, ME
刻板行为神经生物学中药物引起的打哈欠的神经基础
DOI：
--
发表时间：
2003
期刊：
--
影响因子：
--
作者：
C. Dourish;S. Cooper
通讯作者：
S. Cooper