Air pollution, dementia, and lifespan in the socio-economic gradient of aging: perspective on human aging for planning future experimental studies.
Air pollution, dementia, and lifespan in the socio-economic gradient of aging: perspective on human aging for planning future experimental studies.
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DOI：
10.3389/fragi.2023.1273303
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发表时间：
2023
影响因子：
--
通讯作者：
Finch, Caleb E.
中科院分区：
文献类型：
--
作者：
Finch, Caleb E.
空气污染（AirPoll）加速人类衰老，如成人死亡率增加和心血管疾病和痴呆症的早期发作所评估的。财富和教育的社会经济阶层（SES）的死亡率和这些疾病的平行差异。来自贫困家庭的孩子在出生时的大脑发育以及早期脂肪过多和高血压的风险方面有所不同。为了进一步提高健康寿命，老年医学家可能会考虑从妊娠到晚年发病的更广泛的环境暴露，包括老年暴露体。啮齿动物和线虫的实验研究记录了对AirPoll的共同转录反应。在啮齿类动物中，AirPoll暴露通过介导多种衰老过程的Nrf2和NFkB转录因子激活全身解毒的基因系统。遗传环境因素包括母亲的饮食和暴露于AirPoll和香烟烟雾。相应地，妊娠期暴露于AirPoll的小鼠增加了成年体脂肪，葡萄糖清除受损，并减少了海马体中的成年神经发生，海马体是痴呆症中受损的大脑区域。线虫幼虫也会对AirPoll做出与阿尔茨海默病相关的反应。这些实验方法可以确定在SES梯度上扩大人类健康和寿命的干预措施。
Air pollution (AirPoll) accelerates human aging, as assessed by increased adult mortality and earlier onset of cardiovascular diseases, and dementia. Socio-economic strata (SES) of wealth and education have parallel differences of mortality and these diseases. Children from impoverished homes differ in brain development at birth and in risk of early fat excess and hypertension. To further enhance the healthspan, biogerontologists may consider a wider range of environmental exposures from gestation through later life morbidity that comprise the Gero-Exposome. Experimental studies with rodents and nematodes document shared transcriptional responses to AirPoll. In rodents, AirPoll exposure activates gene systems for body-wide detoxification through Nrf2 and NFkB transcription factors that mediate multiple aging processes. Gestational environmental factors include maternal diet and exposure to AirPoll and cigarette smoke. Correspondingly, gestational exposure of mice to AirPoll increased adult body fat, impaired glucose clearance, and decreased adult neurogenesis in the hippocampus, a brain region damaged in dementia. Nematode larvae also respond to AirPoll with Alzheimer relevant responses. These experimental approaches could identify to interventions for expanded human health and longevity across SES gradients.
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DOI：
10.1001/jama.2016.4226
发表时间：
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期刊：
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影响因子：
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