Melt Electrospinning Writing of Poly-Hydroxymethylglycolide-co-ε-Caprolactone-Based Scaffolds for Cardiac Tissue Engineering.
Melt Electrospinning Writing of Poly-Hydroxymethylglycolide-co-ε-Caprolactone-Based Scaffolds for Cardiac Tissue Engineering.
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DOI：
10.1002/adhm.201700311
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发表时间：
2017-09
影响因子：
10
通讯作者：
Malda J
中科院分区：
文献类型：
--
作者：
Castilho M;Feyen D;Flandes-Iparraguirre M;Hochleitner G;Groll J;Doevendans PAF;Vermonden T;Ito K;Sluijter JPG;Malda J
目前心脏组织工程的局限性在于无法完全重现天然心脏组织的结构组织和机械环境。本研究旨在开发与通过溶液静电纺丝获得的传统纤维支架相比具有改善的生物相容性和结构的有组织的超细纤维支架。这是通过将羟基功能化聚酯（聚（羟甲基乙交酯-共聚-ε-己内酯）（pHMGCL）的增材制造与熔体静电纺丝写入（MEW）相结合来实现的。pHMGCL与MEW的使用极大地改善了细胞对机械各向异性的响应。与电纺相比，心脏祖细胞（CPC）能够沿着熔体电纺pHMGCL纤维支架的优先方向更有效地排列总的来说，这项研究首次描述了基于 pHMGCL 的高度有序的微纤维（4.0-7.0 μm）支架可以用 MEW anx0026 重复生成；d 这些支架可以支持和引导 CPC 的生长，从而潜在地增强其治疗潜力。
Current limitations in cardiac tissue engineering revolve around the inability to fully recapitulate the structural organization and mechanical environment of native cardiac tissue. This study aims at developing organized ultrafine fiber scaffolds with improved biocompatibility and architecture in comparison to the traditional fiber scaffolds obtained by solution electrospinning. This is achieved by combining the additive manufacturing of a hydroxyl-functionalized polyester, (poly(hydroxymethylglycolide-co-ε-caprolactone) (pHMGCL), with melt electrospinning writing (MEW). The use of pHMGCL with MEW vastly improves the cellular response to the mechanical anisotropy. Cardiac progenitor cells (CPCs) are able to align more efficiently along the preferential direction of the melt electrospun pHMGCL fiber scaffolds in comparison to electrospun poly(ε-caprolactone)-based scaffolds. Overall, this study describes for the first time that highly ordered microfiber (4.0–7.0 μm) scaffolds based on pHMGCL can be reproducibly generated with MEW anx0026;d that these scaffolds can support and guide the growth of CPCs and thereby potentially enhance their therapeutic potential.
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影响因子：
14
作者：
Aubin H;Nichol JW;Hutson CB;Bae H;Sieminski AL;Cropek DM;Akhyari P;Khademhosseini A
通讯作者：
Khademhosseini A
影响因子：
14
作者：
Charest, JL;Eliason, MT;King, WP
通讯作者：
King, WP
影响因子：
46.9
作者：
Kang, Hyun-Wook;Lee, Sang Jin;Atala, Anthony
通讯作者：
Atala, Anthony
影响因子：
9.7
作者：
Boere, Kristel W. M.;Visser, Jetze;Malda, Jos
通讯作者：
Malda, Jos
影响因子：
4.6
作者：
Tan, SH;Inai, R;Ramakrishna, S
通讯作者：
Ramakrishna, S