Lensfree microscopy on a cellphone.

Lensfree microscopy on a cellphone.
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DOI:
10.1039/c003477k
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发表时间:
2010-07-21
期刊:
影响因子:
6.1
通讯作者:
Ozcan A
Ozcan A
中科院分区:
工程技术1区
文献类型:
--
作者:
Tseng D;Mudanyali O;Oztoprak C;Isikman SO;Sencan I;Yaglidere O;Ozcan A

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我们在手机上演示无透镜数码显微镜。这种小巧轻便的全息显微镜安装在手机上,不使用任何透镜、激光器或其他笨重的光学元件,它可能为远程医疗应用提供一种经济有效的工具,以应对各种全球健康挑战。这个无透镜成像平台重约38克(<1.4盎司),可以机械地连接到手机的相机单元上,从侧面加载样品,并由一个简单的发光二极管(LED)垂直照射。这种非相干的LED光随后从每个微物体散射出来,与背景光相干地干涉,在手机的探测器阵列上形成每个物体的无透镜全息图。手机捕捉到的这些全息特征可以通过快速的数字处理重建物体的显微图像。我们报告了这种无透镜手机显微镜的性能,通过成像各种大小的微粒,以及红细胞,白细胞,血小板和水媒寄生虫(贾第鞭毛虫)。
We demonstrate lensfree digital microscopy on a cellphone. This compact and light-weight holographic microscope installed on a cellphone does not utilize any lenses, lasers or other bulky optical components and it may offer a cost-effective tool for telemedicine applications to address various global health challenges. Weighing ~38 grams (<1.4 ounces), this lensfree imaging platform can be mechanically attached to the camera unit of a cellphone where the samples are loaded from the side, and are vertically illuminated by a simple light-emitting diode (LED). This incoherent LED light is then scattered from each micro-object to coherently interfere with the background light, creating the lensfree hologram of each object on the detector array of the cellphone. These holographic signatures captured by the cellphone permit reconstruction of microscopic images of the objects through rapid digital processing. We report the performance of this lensfree cellphone microscope by imaging various sized micro-particles, as well as red blood cells, white blood cells, platelets and a waterborne parasite (Giardia lamblia).
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