IPD-MHC 2.0: an improved inter-species database for the study of the major histocompatibility complex.
IPD-MHC 2.0: an improved inter-species database for the study of the major histocompatibility complex.
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DOI：
10.1093/nar/gkw1050
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发表时间：
2017-01-04
影响因子：
14.9
通讯作者：
Marsh SG
中科院分区：
文献类型：
--
作者：
Maccari G;Robinson J;Ballingall K;Guethlein LA;Grimholt U;Kaufman J;Ho CS;de Groot NG;Flicek P;Bontrop RE;Hammond JA;Marsh SG
IPD-MHC数据库项目（http：//www.ebi.ac.uk/ipd/mhc/）收集并专业地管理来自非人类物种的主要组织相容性复合体的序列，并提供基础设施和工具以实现准确的分析。自2003年首次发布数据库以来，IPD-MHC已经发展壮大，目前拥有许多特定部分，具有来自70个物种的7000多个等位基因，包括非人灵长类动物，犬科动物，猫科动物，马科动物，鸟类，猪，牛，鲑鱼和鼠科动物。这些序列是专业策划的，并通过一个开放获取的网站公开提供。IPD-MHC数据库是该领域的关键资源，平均每月有1500名独立访问者和超过5000个浏览页面。随着数据库的规模和复杂性的增长，它在维护和组织信息方面带来了许多挑战，特别是需要标准化命名和分类学分类，同时纳入新的等位基因提交。在这里，我们描述了最新的数据库版本，IPD-MHC 2.0，并讨论了计划的发展。此版本包含序列更新和新工具，通过利用能够处理每个MHC组的不同要求的通用工具，增强数据库查询并改进提交程序。
The IPD-MHC Database project (http://www.ebi.ac.uk/ipd/mhc/) collects and expertly curates sequences of the major histocompatibility complex from non-human species and provides the infrastructure and tools to enable accurate analysis. Since the first release of the database in 2003, IPD-MHC has grown and currently hosts a number of specific sections, with more than 7000 alleles from 70 species, including non-human primates, canines, felines, equids, ovids, suids, bovins, salmonids and murids. These sequences are expertly curated and made publicly available through an open access website. The IPD-MHC Database is a key resource in its field, and this has led to an average of 1500 unique visitors and more than 5000 viewed pages per month. As the database has grown in size and complexity, it has created a number of challenges in maintaining and organizing information, particularly the need to standardize nomenclature and taxonomic classification, while incorporating new allele submissions. Here, we describe the latest database release, the IPD-MHC 2.0 and discuss planned developments. This release incorporates sequence updates and new tools that enhance database queries and improve the submission procedure by utilizing common tools that are able to handle the varied requirements of each MHC-group.
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影响因子：
14.9
作者：
Robinson J;Halliwell JA;McWilliam H;Lopez R;Marsh SG
通讯作者：
Marsh SG
影响因子：
14.9
作者：
Cochrane G;Karsch-Mizrachi I;Takagi T;International Nucleotide Sequence Database Collaboration
通讯作者：
International Nucleotide Sequence Database Collaboration
影响因子：
14.9
作者：
Federhen S
通讯作者：
Federhen S
影响因子：
3.2
作者：
de Groot, Natasja G.;Otting, Nel;Robinson, James;Blancher, Antoine;Lafont, Bernard A. P.;Marsh, Steven G. E.;O'Connor, David H.;Shiina, Takashi;Walter, Lutz;Watkins, David I.;Bontrop, Ronald E.
通讯作者：
Bontrop, Ronald E.
影响因子：
2.4
作者：
Tseng, C. T.;Miller, D.;Antczak, D. F.
通讯作者：
Antczak, D. F.