FSH regulates fat accumulation and redistribution in aging through the Gαi/Ca(2+)/CREB pathway.
FSH regulates fat accumulation and redistribution in aging through the Gαi/Ca(2+)/CREB pathway.
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DOI：
10.1111/acel.12331
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发表时间：
2015-06
期刊：
影响因子：
7.8
通讯作者：
Huang HF
中科院分区：
文献类型：
--
作者：
Liu XM;Chan HC;Ding GL;Cai J;Song Y;Wang TT;Zhang D;Chen H;Yu MK;Wu YT;Qu F;Liu Y;Lu YC;Adashi EY;Sheng JZ;Huang HF
脂肪量增加和脂肪重新分布在世界各地的老龄化人群中普遍观察到。虽然已经观察到性激素、雄激素和雌激素的循环水平下降，但衰老过程中脂肪积累和再分布的确切机制仍然不清楚。在这项研究中，卵泡刺激素（FSH）的受体，一种促性腺激素，随着年龄的增长，在男性和女性急剧和持续增加，在人类和小鼠的脂肪组织和脂肪细胞中功能性表达。促卵泡激素可促进脂质合成和脂滴形成; FSH也可改变瘦素和脂联素的分泌，但在体外和体内均不影响增生。FSH的作用由与Gαi蛋白偶联的FSH受体介导;因此，Ca 2+内流被刺激，cAMP反应元件结合蛋白被磷酸化，参与脂质生物合成的一系列基因被激活。目前的研究结果描绘了FSH受体介导的脂肪组织脂肪代谢障碍在衰老中的潜力。我们的研究结果也揭示了男性和女性衰老过程中脂肪积累和再分布的机制。
Increased fat mass and fat redistribution are commonly observed in aging populations worldwide. Although decreased circulating levels of sex hormones, androgens and oestrogens have been observed, the exact mechanism of fat accumulation and redistribution during aging remains obscure. In this study, the receptor of follicle-stimulating hormone (FSH), a gonadotropin that increases sharply and persistently with aging in both males and females, is functionally expressed in human and mouse fat tissues and adipocytes. Follicle-stimulating hormone was found to promote lipid biosynthesis and lipid droplet formation; FSH could also alter the secretion of leptin and adiponectin, but not hyperplasia, in vitro and in vivo. The effects of FSH are mediated by FSH receptors coupled to the Gαi protein; as a result, Ca2+ influx is stimulated, cAMP-response-element-binding protein is phosphorylated, and an array of genes involved in lipid biosynthesis is activated. The present findings depict the potential of FSH receptor-mediated lipodystrophy of adipose tissues in aging. Our results also reveal the mechanism of fat accumulation and redistribution during aging of males and females.
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影响因子：
2.8
作者：
Ausmanas, M. K.;Tan, D. A.;Holinka, C. F.
通讯作者：
Holinka, C. F.
DOI：
10.1152/ajpcell.1998.274.6.c1645
发表时间：
1998-06-01
影响因子：
5.5
作者：
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Giudicelli, Y
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3.5
作者：
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DOI：
10.1016/j.bbalip.2011.09.017
发表时间：
2012-05
期刊：
Biochimica et biophysica acta
影响因子：
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作者：
Jensen-Urstad AP;Semenkovich CF
通讯作者：
Semenkovich CF
DOI：
10.1016/j.bbagen.2009.01.008
发表时间：
2009-10
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Huffman DM;Barzilai N
通讯作者：
Barzilai N