Role of visceral adipose tissue in aging.
Role of visceral adipose tissue in aging.
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DOI：
10.1016/j.bbagen.2009.01.008
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发表时间：
2009-10
期刊：
影响因子：
--
通讯作者：
Barzilai N
中科院分区：
文献类型：
--
作者：
Huffman DM;Barzilai N
内脏脂肪（VF）的增加是人类衰老的标志。流行病学研究表明，腹部肥胖是胰岛素抵抗、2型糖尿病、心血管疾病、中风、代谢综合征和死亡的主要危险因素。利用内脏肥胖的新型啮齿动物模型，研究表明VF和年龄相关疾病之间存在因果关系。相比之下，手术切除大量皮下（SC）腹部脂肪并不能持续改善人类或啮齿动物的代谢参数，这表明SC脂肪积累并不是代谢下降的重要因素。在人类中也有令人信服的证据表明，腹部肥胖是比一般肥胖更强的死亡风险因素。同样，我们已经证明，手术切除VF可以延长大鼠的平均寿命和最长寿命，这提供了第一个因果证据，证明VF耗竭可能是CR延长寿命的重要潜在原因。鉴于VF累积对健康的危害，应将旨在选择性消耗VF的治疗策略视为有效降低人类疾病风险的可行工具。总之，这篇综述提供了推论和因果证据，说明在评估疾病和死亡风险时，考虑体脂分布，特别是VF的重要性。
Visceral fat (VF) accretion is a hallmark of aging in humans. Epidemiologic studies have implicated abdominal obesity as a major risk factor for insulin resistance, type 2 diabetes, cardiovascular disease, stroke, metabolic syndrome and death. Utilizing novel rodent models of visceral obesity, studies have demonstrated a causal relationship between VF and age-related diseases. In contrast, surgically removing large quantities of subcutaneous (SC) abdominal fat does not consistently improve metabolic parameters in humans or rodents, suggesting that SC fat accrual is not an important contributor to metabolic decline. There is also compelling evidence in humans that abdominal obesity is a stronger risk factor for mortality risk than general obesity. Likewise, we have shown that surgical removal of VF improves mean and maximum lifespan in rats, providing the first causal evidence that VF depletion may be an important underlying cause of improved lifespan with CR. Given the hazards of VF accumulation on health, treatment strategies aimed at selectively depleting VF should be considered as a viable tool to effectively reduce disease risk in humans. In summary, this review provides both corollary and causal evidence for the importance of accounting for body fat distribution, and specifically VF, when assessing disease and mortality risk.
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影响因子：
158.5
作者：
Calle, EE;Thun, MJ;Heath, CW
通讯作者：
Heath, CW
影响因子：
5
作者：
Baik, I;Ascherio, A;Willett, WC
通讯作者：
Willett, WC
影响因子：
120.7
作者：
Fontaine, KR;Redden, DT;Allison, DB
通讯作者：
Allison, DB
影响因子：
4.2
作者：
Barzilai, N;Gabriely, I
通讯作者：
Gabriely, I
DOI：
10.1007/bf02581094
发表时间：
1979-01-01
期刊：
ACTA DIABETOLOGICA LATINA
影响因子：
--
作者：
ENZI, G;CAGNONI, G;CREPALDI, G
通讯作者：
CREPALDI, G