Intralaminar and tectal projections to the subthalamus in the rat.
Intralaminar and tectal projections to the subthalamus in the rat.
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DOI：
10.1111/ejn.13413
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Kita H
中科院分区：
文献类型：
--
作者：
Kita T;Shigematsu N;Kita H
在灵长类和啮齿类动物中，丘脑板内后核和上级丘（SC）向丘脑底核和不确定核（ZI）的投射已被描述。本研究的目的是调查这些预测的几个问题，在大鼠中使用现代神经示踪技术，以促进我们的理解的作用，ESTA和ZI。我们研究了投射模式是否可以用来识别同源物的灵长类动物的中央（CM）和束旁核（PF）在啮齿动物，地形的投影，包括什么百分比的intralaminar神经元参与的预测，和电子显微镜检查intralaminar突触终扣在海马。SC-丘脑底投射的目的是检查丘脑是否是投射的主要目标。这项研究显示：（i）在大鼠中可识别出与灵长类CM和Pf相似的区域：（ii）Pf样区向丘脑底核发出非常密集的拓扑结构化投射，但向ZI发出非常稀疏的投射，这表明Pf可能通过丘脑底核控制基底神经节的功能;（iii）CM样区向丘脑底核的投射非常稀疏;（iv）Pf终扣和随机取样的不对称突触在海马神经元树突上的分布相似;以及（v）SC的深层的横向部分向ZI发送非常重的投影并且向有限的部分发送中等到稀疏的投影，提示SC参与基底神经节功能的有限控制。
Projections from the posterior intralaminar thalamic nuclei and the superior colliculus (SC) to the subthalamic nucleus (STN) and the zona incerta (ZI) have been described in the primate and rodent. The aims of this study was to investigate several questions on these projections, using modern neurotracing techniques in rats, to advance our understanding of the role of STN and ZI. We examined whether projection patterns to the subthlamus can be used to identify homologues of the primate centromedian (CM) and the parafascicular nucleus (Pf) in the rodent, the topography of the projection including what percent of intralaminar neurons participate in the projections, and electron microscopic examination of intralaminar synaptic boutons in STN. The aim on the SC‐subthalamic projection was to examine whether STN is the main target of the projection. This study revealed: (i) the areas similar to primate CM and Pf could be recognized in the rat; (ii) the Pf‐like area sends a very heavy topographically organized projection to STN but very sparse projection to ZI, which suggested that Pf might control basal ganglia function through STN; (iii) the projection from the CM‐like area to the subthalamus was very sparse; (iv) Pf boutons and randomly sampled asymmetrical synapses had similar distributions on the dendrites of STN neurons; and (v) the lateral part of the deep layers of SC sends a very heavy projection to ZI and moderate to sparse projection to limited parts of STN, suggesting that SC is involved in a limited control of basal ganglia function.
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DOI：
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发表时间：
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期刊：
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期刊：
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影响因子：
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