Serum BAFF and APRIL levels in patients with IgG4-related disease and their clinical significance.
Serum BAFF and APRIL levels in patients with IgG4-related disease and their clinical significance.
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DOI：
10.1186/ar3810
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发表时间：
2012-04-24
影响因子：
4.9
通讯作者：
Mimori T
中科院分区：
文献类型：
--
作者：
Kiyama K;Kawabata D;Hosono Y;Kitagori K;Yukawa N;Yoshifuji H;Omura K;Fujii T;Mimori T
肿瘤坏死因子家族的B细胞活化因子（BAFF）和增殖诱导配体（APRIL）在B细胞的发育、存活和抗体产生中起着至关重要的作用。本研究分析了免疫球蛋白（Ig） g4相关疾病（IgG4-RD）患者血清BAFF和APRIL水平及其各自的临床相关性。我们测量了IgG4-RD患者、原发性Sjögren综合征（pSS）患者和健康个体的血清BAFF和APRIL水平。评估血清BAFF和IgG4- rd中APRIL水平与血清学参数的相关性，包括Ig，特别是IgG4，以及受影响器官的数量。在糖皮质激素（GC）治疗期间监测血清BAFF和IgG4-RD中的APRIL水平。IgG4-RD患者血清BAFF和APRIL水平显著高于健康人（P < 0.01）。IgG4-RD患者的BAFF水平与pSS患者相当。血清IgG4、受累脏器数量等临床参数与BAFF水平无相关性，但血清APRIL水平与血清IgG4水平呈负相关（r = -0.626, P < 0.05）。虽然GC治疗后血清BAFF水平下降，但随访期间血清APRIL水平升高。这些结果表明BAFF和APRIL可能是预测IgG4-RD疾病活动性的有用标记物。BAFF和APRIL在IgG4-RD发病机制中的作用有待进一步研究。
B cell-activating factor of the tumor necrosis factor family (BAFF) and a proliferation-inducing ligand (APRIL) play a crucial role in B cell development, survival, and antibody production. Here we analyzed the serum levels of BAFF and APRIL and their respective clinical associations in patients with an immunoglobulin (Ig) G4-related disease (IgG4-RD). We measured serum levels of BAFF and APRIL in patients with IgG4-RD, primary Sjögren's syndrome (pSS), and healthy individuals. Serum BAFF and APRIL levels in IgG4-RD were assessed for correlations with serological parameters, including Ig, particularly IgG4, and the number of affected organs. Serum BAFF and APRIL levels in IgG4-RD were monitored during glucocorticoid (GC) therapy. Serum BAFF and APRIL levels in patients with IgG4-RD were significantly higher (P < 0.01) than in healthy individuals. The BAFF levels of patients with IgG4-RD were comparable to those of patients with pSS. Although clinical parameters, such as serum IgG4 and the number of affected organs, were not correlated with the levels of BAFF, serum APRIL levels were inversely correlated with serum IgG4 levels (r = -0.626, P < 0.05). While serum BAFF levels decreased following GC therapy, serum APRIL levels increased during follow-up. These results indicate that BAFF and APRIL might be useful markers for predicting disease activity in IgG4-RD. Further studies are needed to elucidate the role of BAFF and APRIL in the pathogenesis of IgG4-RD.
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影响因子：
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作者：
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