Salmonella pathogenesis and host-adaptation in farmed animals.
Salmonella pathogenesis and host-adaptation in farmed animals.
复制标题
养殖动物的沙门氏菌发病机制和宿主适应。
DOI：
10.1016/j.mib.2021.05.013
复制
发表时间：
2021
影响因子：
5.4
通讯作者：
Stevens MP
中科院分区：
文献类型：
--
作者：
Stevens MP
亮点沙门氏菌宿主适应和毒力的基因组特征正在出现。序列分析可以帮助预测人畜共患风险和来源归因。宿主特异性、生态位特异性和变异特异性毒力因子已被鉴定。比较和功能基因组学确定了控制沙门氏菌的选项。啮齿动物和细胞检测并不总是反映农场动物中的沙门氏菌病。沙门氏菌是 具有全球重要性的动物和人畜共患病病原体。根据病原体和宿主因素，感染可能无症状或涉及急性胃肠炎或侵袭性疾病。与肠道沙门氏菌血清型及其变种的宿主范围、组织向性或毒力差异相关的基因组特征已经出现。反过来，通过序列数据预测沙门氏菌的入侵潜力、宿主适应和人畜共患病风险变得可行，以改进疫情调查、风险评估和控制策略。随着高密度突变文库的筛选，沙门氏菌基因组的功能注释加速，揭示了宿主特异性、生态位特异性和血清型特异性毒力因子。作为天然宿主和宿主，养殖动物为沙门氏菌的宿主适应和发病机制提供了强有力的见解，而这在替代啮齿动物或基于细胞的模型中并不总是显而易见的。
HighlightsGenomic signatures of host-adaptation and virulence of Salmonella are emerging.Sequence analyses can aid the prediction of zoonotic risk and source attribution.Host-specific, niche-specific and variant-specific virulence factors have been identified.Comparative and functional genomics identify options for control of Salmonella.Rodent and cell-based assays do not always reflect salmonellosis in farm animals.Salmonella is an animal and zoonotic pathogen of global importance. Depending on pathogen and host factors, infections can be asymptomatic or involve acute gastroenteritis or invasive disease. Genomic signatures associated with host-range, tissue tropism or differential virulence of Salmonella enterica serovars, and their variants, have emerged. In turn, it is becoming feasible to predict invasive potential, host-adaptation and zoonotic risk of Salmonella from sequence data to improve outbreak investigation, risk assessment and control strategies. Functional annotation of Salmonella genomes has accelerated with the screening of high-density mutant libraries, revealing host-specific, niche-specific and serovar-specific virulence factors. As natural hosts and reservoirs, farmed animals provide powerful insights into host-adaptation and pathogenesis of Salmonella not always evident from surrogate rodent or cell-based models.
登录
查看更多内容
影响因子：
30.3
作者：
Bronner DN;Faber F;Olsan EE;Byndloss MX;Sayed NA;Xu G;Yoo W;Kim D;Ryu S;Lebrilla CB;Bäumler AJ
通讯作者：
Bäumler AJ
影响因子：
4.6
作者：
Tambassi M;Berni M;Bracchi C;Scaltriti E;Morganti M;Bolzoni L;Tanner JR;Thilliez G;Kingsley RA;Pongolini S;Casadei G
通讯作者：
Casadei G
影响因子：
30.3
作者：
Kroeger, Carsten;Colgan, Aoife;Hinton, Jay C. D.
通讯作者：
Hinton, Jay C. D.
人为选择和生态位适应驱动的肠沙门氏菌血清型鼠伤寒进化
DOI：
10.1101/804674
发表时间：
2019
期刊：
--
影响因子：
--
作者：
Bawn M
通讯作者：
Bawn M
牛肠道沙门氏菌都柏林血清型的全身易位主要通过无细胞生态位中的传出淋巴管发生，需要 III 型分泌系统 1 (T3SS-1)，但不需要 T3SS-2
影响因子：
3.1
作者：
G. Pullinger;S. Paulin;B. Charleston;P. Watson;A. Bowen;F. Dziva;E. Morgan;B. Villarreal;T. Wallis;M. Stevens
通讯作者：
M. Stevens