Decreased feedback learning in anorexia nervosa persists after weight restoration.
Decreased feedback learning in anorexia nervosa persists after weight restoration.
复制标题
神经性厌食症的反馈学习减少在体重恢复后仍然存在。
DOI：
10.1002/eat.22709
复制
发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
Steinglass JE
中科院分区：
文献类型：
--
作者：
Foerde K;Steinglass JE
神经性厌食症（AN）是一种严重的疾病，其死亡率是所有精神疾病中最高的。众所周知，治疗具有挑战性，并且疾病的机制尚未得到很好的理解。奖励系统异常已经在AN持续性的理论模型中提出。反馈学习是奖励系统如何塑造行为的一个重要组成部分，我们假设患有AN的个体从反馈中的学习效果较差。我们管理的获得性等效任务，以衡量学习从增量反馈和概括的学习，以新的刺激。参与者是在强化体重恢复治疗前后患有AN的个体（n=36）和健康对照（HC，n=26），测试两次。在学习和测试阶段，对训练和新刺激的准确性进行了评估。还评估了基线时任务表现和进食障碍严重程度之间的关系。治疗前后，与HC相比，AN患者在学习阶段（F3，180=2.75，p=0.048）的反馈学习减少，在测试阶段（F1，60=4.29，p=0.043）的准确性降低。AN患者在新刺激的准确性方面与HC没有差异（F1，60=1.04，p=0.312），表明在泛化方面没有缺陷。获得反馈学习的减少与较长的病程和基线时更严重的进食障碍症状相关。AN患者从反馈或强化中学习的能力降低，这可能导致难以改变适应不良的行为。
Anorexia Nervosa (AN) is a serious disorder, with a mortality rate the highest of any psychiatric illness. It is notoriously challenging to treat and mechanisms of illness are not well understood. Reward system abnormalities have been proposed across theoretical models of the persistence of AN. Feedback learning is an important component of how reward systems shape behavior and we hypothesized that individuals with AN would show poorer learning from feedback. We administered the Acquired Equivalence Task to measure both learning from incremental feedback and generalization of that learning to novel stimuli. Participants were individuals with AN (n=36) before and after intensive weight restoration treatment and healthy controls (HC, n=26) tested twice. Performance was assessed as accuracy during the Learning and Test phases, for both trained and novel stimuli. The relationship between task performance and eating disorder severity at baseline was also assessed. Both before and after treatment, individuals with AN showed reduced learning from feedback in the Learning phase (F3,180=2.75, p=0.048) and lower accuracy during the Test phase (F1,60=4.29, p=0.043), as compared with HC. Individuals with AN did not differ from HC in accuracy for novel stimuli (F1,60=1.04, p=0.312), indicating no deficit in generalization. Decreased acquisition of feedback learning was associated with longer illness duration and with greater eating disorder symptom severity at baseline. Individuals with AN show reduced learning from feedback or reinforcement, which may contribute to difficulties in changing maladaptive behaviors.
登录
查看更多内容
影响因子：
14.8
作者：
Bowie, Christopher R.;Harvey, Philip D.
通讯作者：
Harvey, Philip D.
影响因子：
1.4
作者：
Herzallah, Mohammad M.;Moustafa, Ahmed A.;Gluck, Mark A.
通讯作者：
Gluck, Mark A.
影响因子：
5.4
作者：
Bakeman, R
通讯作者：
Bakeman, R
影响因子：
1.4
作者：
Bodi, Nikoletta;Csibri, Eva;Keri, Szabolcs
通讯作者：
Keri, Szabolcs
影响因子：
25
作者：
Foerde K;Steinglass JE;Shohamy D;Walsh BT
通讯作者：
Walsh BT