Retrospective analysis of demographic factors in COVID-19 patients entering the Mount Sinai Health System.
Retrospective analysis of demographic factors in COVID-19 patients entering the Mount Sinai Health System.
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DOI：
10.1371/journal.pone.0254707
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Fish K
中科院分区：
文献类型：
--
作者：
Eskandari A;Brojakowska A;Bisserier M;Bander J;Garikipati VNS;Hadri L;Goukassian D;Fish K
随着COVID-19感染全球发病率的持续上升和第二波疫情的出现，了解影响感染易感性、临床严重程度和结局的特征仍然至关重要。本研究的目的是在一个大型、多样化的单一卫生系统队列中评估人口统计学因素对COVID-19检测状态和结果的修正效应。西奈山卫生系统去识别COVID-19数据库包含2020年2月28日至2020年6月8日期间进入卫生系统的39，539名患者的记录，其中有7，032例实验室确诊病例。qRT-PCR鼻咽拭子的患病率（χ2 = 665.7，p<0.0001）和病例率（χ2 = 445.3，p<0.0001）在西班牙裔和黑人或非裔美国人中最高。入院和/或就诊于重症监护室（ICU）与非ICU住院病房、急诊科和门诊服务的可能性（反映了临床病程的严重程度）也根据人种和种族进行了修改。女性受试者较少[相对危险度（RR）= 1.121，p<0.0001]，男性患病率较高（RR = 1.224，p<0.001）。与其他主要族裔群体相比，白人的死亡率较高（p<0.05）。与女性（73.02±11.46）（p = 0.0004）相比，男性在相对较年轻的年龄（70.58±11.75）时经历了更高的死亡风险（RR = 1.180，p = 0.0012）。在老年患者人群中，疾病的严重程度增加。虽然西班牙裔和黑人或非洲裔美国人的种族与较高的检测流行率和阳性检测率，唯一的差异就死亡率是一个较高的流行率在白人。
With the continued rise of the global incidence of COVID-19 infection and emergent second wave, the need to understand characteristics that impact susceptibility to infection, clinical severity, and outcomes remains vital. The objective of this study was to assess modifying effects of demographic factors on COVID-19 testing status and outcomes in a large, diverse single health system cohort. The Mount Sinai Health System de-identified COVID-19 database contained records of 39,539 patients entering the health system from 02/28/2020 to 06/08/2020 with 7,032 laboratory-confirmed cases. The prevalence of qRT-PCR nasopharyngeal swabs (χ2 = 665.7, p<0.0001) and case rates (χ2 = 445.3, p<0.0001) are highest in Hispanics and Black or African Americans. The likelihood of admission and/or presentation to an intensive care unit (ICU) versus non-ICU inpatient unit, emergency department, and outpatient services, which reflects the severity of the clinical course, was also modified by race and ethnicity. Females were less likely to be tested [Relative Risk(RR) = 1.121, p<0.0001], and males had a higher case prevalence (RR = 1.224, p<0.001). Compared to other major ethnic groups, Whites experienced a higher prevalence of mortality (p<0.05). Males experienced a higher risk of mortality (RR = 1.180, p = 0.0012) at relatively younger ages (70.58±11.75) compared to females (73.02±11.46) (p = 0.0004). There was an increased severity of disease in older patient populations of both sexes. Although Hispanic and Black or African American race was associated with higher testing prevalence and positive testing rates, the only disparity with respect to mortality was a higher prevalence in Whites.
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DOI：
10.1016/s1473-3099(10)70049-9
发表时间：
2010-05
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Klein SL;Jedlicka A;Pekosz A
通讯作者：
Pekosz A
影响因子：
2
作者：
Boissier, J;Chlichlia, K;Moné, H
通讯作者：
Moné, H
影响因子：
64.8
作者：
Zhou, Peng;Yang, Xing-Lou;Shi, Zheng-Li
通讯作者：
Shi, Zheng-Li
影响因子：
5
作者：
Hamouche W;Bisserier M;Brojakowska A;Eskandari A;Fish K;Goukassian DA;Hadri L
通讯作者：
Hadri L
影响因子：
3.2
作者：
Bukowska, A.;Spiller, L.;Goette, A.
通讯作者：
Goette, A.