Cortical adult neurogenesis and its biological implication

Cortical adult neurogenesis and its biological implication
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皮质成人神经发生及其生物学意义

DOI:
10.1111/cen3.12652
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发表时间:
2021
影响因子:
--
通讯作者:
Ohira Koji
Ohira Koji
中科院分区:
--
文献类型:
--
作者:
高坂洋史;Ohira Koji

文献摘要

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成熟期的神经发生主要发生在脑室下区和颗粒下区,但对其他区域的神经发生仍存在争议。大脑皮层是最有争议的部位,自世纪末以来,不仅神经科学家,而且具有广泛背景的科学家和医生都对它感兴趣。然而,最近的研究逐渐阐明,在成人大脑皮层神经发生,特别是在病理条件下。这些研究表明,内源性神经干细胞和/或祖细胞可能存在于大脑皮层中或周围,并可用于脑损伤和疾病的再生细胞治疗。在这篇综述中,总结了最近关于成人大脑皮质神经发生的文献,并讨论了细胞治疗皮质相关疾病的可能性。
It is well established that adult neurogenesis occurs in the subventricular zone and the subgranular zone, but a controversy remains about adult neurogenesis in other regions. The cerebral cortex is the most controversial site and has long been of interest to not only neuroscientists, but also scientists with broad backgrounds and medical doctors since the late 19th century. However, recent studies have been gradually clarifying that neurogenesis in the adult cerebral cortex occurs, especially under pathological conditions. These studies suggest that endogenous neural stem cells and/or progenitor cells might exist in or around the cerebral cortex, and be useful for regenerative cell therapy in cases of brain insults and diseases. In this review, recent literature regarding neurogenesis in the adult cerebral cortex is summarized, and the possibility of cell therapy for cortex‐related disorders is discussed.
DOI: 10.1523/jneurosci.23-03-00937.2003
发表时间: 2003-02
期刊: The Journal of Neuroscience
影响因子: --
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