Emotional prosodic change detection in autism Spectrum disorder: an electrophysiological investigation in children and adults.
Emotional prosodic change detection in autism Spectrum disorder: an electrophysiological investigation in children and adults.
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DOI：
10.1186/s11689-018-9246-9
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发表时间：
2018-09-18
影响因子：
4.9
通讯作者：
Gomot M
中科院分区：
文献类型：
--
作者：
Charpentier J;Kovarski K;Houy-Durand E;Malvy J;Saby A;Bonnet-Brilhault F;Latinus M;Gomot M
自闭症谱系障碍（ASD）的特点是在社会环境中表现出非典型行为，以及对变化事件的反应。虽然这两种症状与非典型感觉行为一起是病理的核心，但大多数研究只调查了一个维度。对相同维度的关注表明，对变化的不耐受与非典型的注意前检测不规则性有关。在本研究中，我们探讨了对情绪变化的相同反应过程，以评估儿童和成人自闭症患者的变化检测和社会情绪加工的变化之间的相互作用。记录了自闭症儿童、成人和对照组对中性和情绪性韵律偏差（失配负性（MMN）和P3a，分别反映变化检测和对变化的注意取向）的大脑反应。中性条件和情绪条件的比较可以区分一般偏差和情绪偏差的影响。此外，记录大脑对同样的中性刺激和情绪刺激的反应，当它们不偏离时，以评估这些声音刺激的感觉处理。在对照组中，变化检测是由韵律调节的：在儿童中，其特点是情绪MMN向右半球偏侧，在成人中，情绪偏差的MMN比中性偏差的MMN更早。在ASD中，与对照组相比，MMN更早，P3a更大，总体上观察到非典型变化检测，这表明对听觉环境的任何变化都有不寻常的注意前取向。此外，在自闭症儿童中，异常检测显示MMN振幅降低。此外，与成人自闭症患者相反，自闭症儿童的MMN不受韵律的调节，对中性和情绪性声音刺激的感觉加工也不典型。总的来说，自闭症患者的变化检测仍然有所改变。然而，儿童和成人自闭症患者之间的差异表明，随着年龄的增长，声音处理和情绪异常的自动检测趋于正常化。
Autism spectrum disorder (ASD) is characterized by atypical behaviors in social environments and in reaction to changing events. While this dyad of symptoms is at the core of the pathology along with atypical sensory behaviors, most studies have investigated only one dimension. A focus on the sameness dimension has shown that intolerance to change is related to an atypical pre-attentional detection of irregularity. In the present study, we addressed the same process in response to emotional change in order to evaluate the interplay between alterations of change detection and socio-emotional processing in children and adults with autism. Brain responses to neutral and emotional prosodic deviancies (mismatch negativity (MMN) and P3a, reflecting change detection and orientation of attention toward change, respectively) were recorded in children and adults with autism and in controls. Comparison of neutral and emotional conditions allowed distinguishing between general deviancy and emotional deviancy effects. Moreover, brain responses to the same neutral and emotional stimuli were recorded when they were not deviants to evaluate the sensory processing of these vocal stimuli. In controls, change detection was modulated by prosody: in children, this was characterized by a lateralization of emotional MMN to the right hemisphere, and in adults, by an earlier MMN for emotional deviancy than for neutral deviancy. In ASD, an overall atypical change detection was observed with an earlier MMN and a larger P3a compared to controls suggesting an unusual pre-attentional orientation toward any changes in the auditory environment. Moreover, in children with autism, deviancy detection depicted reduced MMN amplitude. In addition in children with autism, contrary to adults with autism, no modulation of the MMN by prosody was present and sensory processing of both neutral and emotional vocal stimuli appeared atypical. Overall, change detection remains altered in people with autism. However, differences between children and adults with ASD evidence a trend toward normalization of vocal processing and of the automatic detection of emotion deviancy with age.
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DOI：
10.1044/1092-4388(2009/08-0127
发表时间：
2010-06-01
影响因子：
2.6
作者：
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