Temporal lobe volume in bipolar disorder: relationship with diagnosis and antipsychotic medication use.
Temporal lobe volume in bipolar disorder: relationship with diagnosis and antipsychotic medication use.
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DOI：
10.1016/j.jad.2008.07.003
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发表时间：
2009-04
影响因子：
6.6
通讯作者：
Taylor, Warren D.
中科院分区：
文献类型：
--
作者：
Jones, Lindsay D.;Payne, Martha E.;Messer, Denise F.;Beyer, John L.;MacFall, James R.;Krishnan, K. Ranga R.;Taylor, Warren D.
关键词：
我们测试了双相情感障碍患者颞叶体积的差异以及这些体积与精神药物使用之间的关系。125名双相情感障碍受试者和87名无精神疾病的对照受试者完成了临床访谈和1.5T MRI脑扫描。颞叶体积手动跟踪和分割成灰质和白色物质体积使用自动化过程。一般线性模型研究这些体积和诊断之间的关系作为主要预测因素，年龄，性别，教育和种族作为辅助预测因素。次要分析将精神药物的使用纳入线性模型，并通过向后回归开发简约模型。在初始模型中，双相情感障碍受试者双侧颞叶白色物质较大（左侧：F1，211 = 2.86，p = 0.0047;右侧：F1，211 = 3.25，p = 0.0014）。目前使用抗精神病药物与双侧颞叶白色物质体积较大显著相关（左：F2，211 = 9.45，p = 0.0001;右：F2，211 = 10.79，p < 0.0001），其中双相情感障碍受试者服用抗精神病药物的体积大于双相情感障碍受试者不服用抗精神病药物或健康对照受试者。颞叶灰质体积与诊断或药物使用无显著相关性。排除物质使用障碍受试者可能会限制研究的普遍性。这些发现表明颞叶白色物质的差异与双相情感障碍和抗精神病药物的使用有关。
We tested for differences in temporal lobe volume in bipolar disorder and the relationship between these volumes and psychotropic medication use. 125 subjects with bipolar disorder and 87 comparison subjects with no psychiatric illness completed clinical interviews and 1.5T MRI brain scans. Temporal lobe volumes were manually traced and segmented into gray matter and white matter volumes using an automated process. General linear models examined the relationship between these volumes and diagnosis as the primary predictor with age, sex, education, and race as copredictors. Secondary analyses incorporated the use of psychotropic medication into the linear models, and parsimonious models developed through backwards regression. In initial models, subjects with bipolar disorder exhibited larger temporal lobe white matter bilaterally (left: F1,211 = 2.86, p = 0.0047; right: F1,211 = 3.25, p = 0.0014). Current antipsychotic use was significantly associated with larger bilateral temporal lobe white matter volumes (left: F2,211 = 9.45, p = 0.0001; right: F2,211 = 10.79, p < 0.0001), wherein bipolar subjects taking antipsychotics had larger volumes than bipolar subjects not taking antipsychotics or healthy comparison subjects. Temporal lobe gray matter volume was not significantly associated with diagnosis or medication use. Excluding subjects with substance use disorders may limit the study’s generlizability. These findings indicate that differences in temporal lobe white matter are associated with bipolar disorder and use of antipsychotic medications.
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