Urinary oxygen tension measurement in humans using magnetic resonance imaging.
Urinary oxygen tension measurement in humans using magnetic resonance imaging.
复制标题
DOI：
10.1016/j.acra.2008.04.013
复制
发表时间：
2008-11
影响因子：
4.8
通讯作者：
Yeh, Benjamin M.
中科院分区：
文献类型：
--
作者：
Wang, Zhen J.;Joe, Bonnie N.;Coakley, Fergus V.;Zaharchuk, Greg;Busse, Reed;Yeh, Benjamin M.
肾髓质缺氧常与肾功能不全有关；肾盂尿氧压（pO2）可作为邻近肾髓质氧合的替代指标。我们的目的是评估磁共振定量人类尿pO2的可行性。液体的纵向松弛度（R1）与pO2线性相关，允许MR定量尿液pO2。我们使用实时饱和度恢复t2制备的SSFSE序列对尿液幻影进行pO2范围成像，以校准尿液R1值至pO2。经IRB批准，我们对7名健康受试者在呼吸室内空气时进行了膀胱成像，对9名健康受试者在呼吸室内空气或100% O2时通过面罩进行了肾盂成像。比较100% O2呼吸前后肾盆腔尿液pO2的变化。我们的幻影研究证实尿液R1与pO2线性相关：pO2 (mmHg) = (R1 - 0.2253 s−1)/(2.61e−4 s−1/mmHg)。7名受试者的平均膀胱尿pO2在23 ~ 45 mm Hg之间。在9名健康受试者中，有7名获得了肾盆腔尿液pO2的成功MR测量。呼吸100%O2后，肾盆腔尿液pO2平均升高29 mmHg （p<0.05）。我们表明MR定量尿pO2是可行的。无创肾盆腔尿液pO2测定可作为肾髓质氧合的一种有价值的间接测量方法，允许临床研究肾髓质缺氧在肾脏疾病中的作用。
Renal medullary hypoxia is frequently implicated in renal dysfunction; and urinary oxygen tension (pO2) in the renal pelvis can be used as a surrogate for the adjacent renal medullary oxygenation. We aim to assess the feasibility of MR quantification of urinary pO2 in humans. The longitudinal relaxivity (R1) of fluids is linearly related to pO2, allowing MR quantification of urinary pO2. We imaged urine phantoms with a range of pO2 using a real time saturation recovery T2-prepped SSFSE sequence to calibrate urine R1 values to pO2. Following IRB approval, we imaged the urinary bladders of 7 healthy subjects while breathing room air, and the renal pelvis of 9 healthy subjects breathing room air or 100% O2 via facemask. The renal pelvic urine pO2 was compared before, during and after 100% O2 breathing. Our phantom study confirmed that urine R1 is linearly related to pO2: pO2 (mmHg) = (R1 – 0.2253 s−1)/(2.61e−4 s−1/mmHg). The mean bladder urine pO2 ranged from 23 to 45 mm Hg among the 7 subjects. Successful MR measurements of renal pelvic urine pO2 were obtained in 7 of 9 healthy subjects. Following 100%O2 breathing, the renal pelvic urine pO2 showed a significant mean increase of 29 mmHg (p<0.05). We show that MR quantification of urinary pO2 is feasible. Noninvasive renal pelvic urine pO2 determinations could serve as a valuable indirect measure for renal medullary oxygenation, allowing for clinical investigations of the role of renal medullary hypoxia in renal disease.
登录
查看更多内容
影响因子：
3.3
作者：
BRITTAIN, JH;HU, BS;NISHIMURA, DG
通讯作者：
NISHIMURA, DG
影响因子：
6.6
作者：
LANDES, RR;DURUMAN, N;LEONHARDT, KO
通讯作者：
LEONHARDT, KO
DOI：
10.1007/bf02731333
发表时间：
1955-01-01
期刊：
NUOVO CIMENTO
影响因子：
--
作者：
CHIAROTTI, G;CRISTIANI, G;GIULOTTO, L
通讯作者：
GIULOTTO, L
影响因子：
1.2
作者：
Stafford-Smith, M;Grocott, HP
通讯作者：
Grocott, HP
影响因子：
37.8
作者：
Prasad, PV;Edelman, RR;Epstein, FH
通讯作者：
Epstein, FH