Physical activity and risk of cardiovascular disease--a meta-analysis of prospective cohort studies.
Physical activity and risk of cardiovascular disease--a meta-analysis of prospective cohort studies.
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体育锻炼与心血管疾病风险--前瞻性队列研究荟萃分析。
DOI：
10.3390/ijerph9020391
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发表时间：
2012-02
影响因子：
--
通讯作者：
Siegrist J
中科院分区：
文献类型：
--
作者：
Li J;Siegrist J
为了通过对前瞻性队列研究的数据应用荟萃分析随机效应模型来更新和改进体力活动（PA）与心血管疾病（CVD）相关性的现有证据，使用高质量的研究选择标准，我们检索了PubMed数据库，从1980年1月到2010年12月，寻找PA和事件CVD的前瞻性队列研究，区分职业PA和休闲时间PA，分别为冠心病和中风。纳入标准为具有原始数据的同行评议英文论文、大样本量（n ≥ 1，000）和大量随访（≥5年）的研究、主要混杂因素和相对风险（RR）或风险比（HR）估计值的可用数据以及95%置信区间（CI）。我们在总体分析中纳入了21项前瞻性研究，样本量超过650，000名最初没有CVD的成年人，随访期间记录了约20，000例事件。在男性中，高休闲时间PA组与低休闲时间PA对照组相比，总体CVD的RR为0.76（95% CI 0.70-0.82，p < 0.001），有明显的剂量反应关系。在女性中观察到类似的效果（RR = 0.73，95% CI 0.68-0.78，p < 0.001）。在男性（RR = 0.89，95%CI 0.82-0.97，p = 0.008）和女性（RR = 0.83，95%CI 0.67-1.03，p = 0.089）中，观察到职业性PA的中度保护作用。未观察到发表偏倚。我们的研究结果表明，高水平的休闲时间PA和中等水平的职业PA对心血管健康具有有益的影响，可以将男性和女性冠心病和中风的总体风险分别降低20%至30%和10%至20%。来自高质量研究的证据支持经济发达国家和快速发展中国家的心血管疾病一级和二级预防工作。
In order to update and improve available evidence on associations of physical activity (PA) with cardiovascular disease (CVD) by applying meta-analytic random effects modeling to data from prospective cohort studies, using high quality criteria of study selection, we searched the PubMed database from January 1980 to December 2010 for prospective cohort studies of PA and incident CVD, distinguishing occupational PA and leisure time PA, coronary heart disease (CHD) and stroke, respectively. Inclusion criteria were peer-reviewed English papers with original data, studies with large sample size (n ≥ 1,000) and substantial follow-up (≥5 years), available data on major confounders and on estimates of relative risk (RR) or hazard ratio (HR), with 95% confidence intervals (CI). We included 21 prospective studies in the overall analysis, with a sample size of more than 650,000 adults who were initially free from CVD, and with some 20,000 incident cases documented during follow-up. Among men, RR of overall CVD in the group with the high level of leisure time PA was 0.76 (95% CI 0.70–0.82, p < 0.001), compared to the reference group with low leisure time PA, with obvious dose-response relationship. A similar effect was observed among women (RR = 0.73, 95% CI 0.68–0.78, p < 0.001). A strong protective effect of occupational PA was observed for moderate level in both men (RR = 0.89, 95% CI 0.82–0.97, p = 0.008) and women (RR = 0.83, 95% CI 0.67–1.03, p = 0.089). No publication bias was observed. Our findings suggest that high level of leisure time PA and moderate level of occupational PA have a beneficial effect on cardiovascular health by reducing the overall risk of incident coronary heart disease and stroke among men and women by 20 to 30 percent and 10 to 20 percent, respectively. This evidence from high quality studies supports efforts of primary and secondary prevention of CVD in economically advanced as well as in rapidly developing countries.
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影响因子：
5
作者：
KIELY, DK;WOLF, PA;KANNEL, WB
通讯作者：
KANNEL, WB
影响因子：
8.3
作者：
Lee, IM;Paffenbarger, RS
通讯作者：
Paffenbarger, RS
影响因子：
12.7
作者：
DONAHUE, RP;ABBOTT, RD;YANO, K
通讯作者：
YANO, K
影响因子：
18.4
作者：
Holtermann, A.;Hansen, J. V.;Sjogaard, G.
通讯作者：
Sjogaard, G.
DOI：
10.1097/00005768-200106001-00017
发表时间：
2001-06-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Kohl, HW
通讯作者：
Kohl, HW