Novel parameter based on lipid indicators ratio improves prognostic value of plasma lipid levels in resectable colorectal cancer patients.
Novel parameter based on lipid indicators ratio improves prognostic value of plasma lipid levels in resectable colorectal cancer patients.
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DOI：
10.4240/wjgs.v13.i7.689
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发表时间：
2021-07-27
影响因子：
2
通讯作者：
Cai KL
中科院分区：
文献类型：
--
作者：
Gu JN;Yao S;Cao YH;Deng SH;Mao FW;Jiang HY;He YT;Li XY;Ke SQ;Li HL;Li H;Liu XH;Liu HL;Wang JL;Wu K;Liu L;Cai KL
目前，血脂指标在评估结直肠癌预后方面的价值还比较有限。评估基于术前血脂水平的结直肠癌 (CRC) 预后评分新参数的价值。检测了四种关键的血清脂质因子，即高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白A1（ApoA1）和载脂蛋白B（ApoB）。计算了两个代表性比率，HDL-C-LDL-C比率（HLR）和ApoA1-ApoB比率（ABR）。通过Kaplan-Meier图和Cox比例风险回归分析这些参数与CRC患者预后（包括无进展生存期（PFS）和总生存期（OS））的关系。建立了一种基于HLR和ABR的新型脂蛋白胆固醇-载脂蛋白（LA）评分，并探讨其在CRC患者预后评估中的价值。 PFS和OS的多变量Cox比例风险回归分析显示HDL-C、ApoA1、HLR和ABR与CRC患者的预后呈正相关。 LA 评分与可切除 CRC 患者的良好预后独立相关。虚拟变量的数据处理表明，LA评分较高的患者预后优于LA评分较低的患者。新建立的 LA 评分可能可以作为可切除结直肠癌患者预后的更好预测指标。
At present, the value of lipid indicators in evaluating the prognosis of colorectal cancer is still relatively limited. To evaluate the value of a novel parameter for colorectal cancer (CRC) prognosis scoring based on preoperative serum lipid levels. Four key serum lipid factors, namely, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (ApoA1), and apolipoprotein B (ApoB), were detected. Two representative ratios, HDL-C-LDL-C ratio (HLR) and ApoA1-ApoB ratio (ABR) were calculated. The relationship of these parameters with the prognosis of CRC patients including progression-free survival (PFS) and overall survival (OS) was analyzed by Kaplan-Meier plot and Cox proportional hazards regression. A novel lipoprotein cholesterol-apolipoprotein (LA) score based on HLR and ABR was established and its value in prognosis evaluation for CRC patients was explored. Multivariate Cox proportional hazards regression analysis of PFS and OS showed that HDL-C, ApoA1, HLR, and ABR were positively associated with the prognosis of CRC patients. LA score was independently associated with a good prognosis in resectable CRC patients. Data processing of a dummy variable showed that the prognosis of patients with higher LA scores is better than that with lower LA scores. The newly established LA score might serve as a better predictor of the prognosis of resectable CRC patients.
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影响因子：
13.6
作者：
Choi, Yoon Jin;Lee, Dong Ho;Kim, Nayoung
通讯作者：
Kim, Nayoung
影响因子：
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作者：
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24
作者：
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27.4
作者：
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通讯作者：
Iwamoto, Y
影响因子：
7.2
作者：
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通讯作者：
Hagemann T