Spatiotemporal dynamics of noradrenaline during learned behaviour.
Spatiotemporal dynamics of noradrenaline during learned behaviour.
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学习行为过程中去甲肾上腺素的时空动态
DOI：
10.1038/s41586-022-04782-2
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发表时间：
2022-06
期刊：
影响因子：
64.8
通讯作者：
中科院分区：
文献类型：
--
作者：
从蓝斑释放的去甲肾上腺素是一种普遍存在的神经调节剂，与唤醒、动作和感觉增益以及学习等多种功能有关。LC （LC- na）中表达去甲肾上腺素的神经元是否以及如何激活促进特定行为的不同组成部分尚不清楚。本研究表明，在学习行为过程中，LC-NA活动表现出不同的时空动态，从而实现两种功能——促进任务执行和编码强化，以提高性能准确性。为了检验这些功能，我们对听觉刺激分级检测和任务表现的小鼠进行了行为任务。LC的光遗传失活表明LC- na活性是任务执行和优化的原因。利用照片标记、双光子显微内窥镜和双光子输出监测对LC-NA神经元进行定向记录，发现瞬时LC-NA激活先于行为执行，随后是强化。这两种相活动成分在LC-NA皮层输出中呈现异质性，因此行为反应信号在运动皮层较高，有助于任务执行，而负强化信号在皮层区域广泛分布，在随后的试验中提高了反应敏感性。因此，LC输出的模块化靶向可以实现多种功能，其中一些去甲肾上腺素信号在靶标之间分离，而另一些则广泛分布。
Noradrenaline released from the locus coeruleus (LC) is a ubiquitous neuromodulator that has been linked to multiple functions including arousal, action and sensory gain, and learning. Whether and how activation of noradrenaline-expressing neurons in the LC (LC-NA) facilitates different components of specific behaviors is unknown. Here we show that LC-NA activity displays distinct spatiotemporal dynamics to enable two functions during learned behavior – facilitating task execution and encoding reinforcement to improve performance accuracy. To examine these functions, we used a behavioral task in mice with graded auditory stimulus detection and task performance. Optogenetic inactivation of the LC demonstrated that LC-NA activity was causal for both task execution and optimization. Targeted recordings of LC-NA neurons using photo-tagging, two-photon micro-endoscopy and two-photon output monitoring, showed that transient LC-NA activation preceded behavioral execution and followed reinforcement. These two components of phasic activity were heterogeneously represented in LC-NA cortical outputs, such that the behavioral response signal was higher in the motor cortex and facilitated task execution, whereas the negative reinforcement signal was widely distributed among cortical regions and improved response sensitivity on the subsequent trial. Modular targeting of LC outputs thus enables diverse functions, whereby some noradrenaline signals are segregated amongst targets while others are broadly distributed.
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神经元型特异性信号，用于腹侧对段区域的奖励和惩罚。
影响因子：
64.8
作者：
Cohen, Jeremiah Y.;Haesler, Sebastian;Vong, Linh;Lowell, Bradford B.;Uchida, Naoshige
通讯作者：
Uchida, Naoshige
影响因子：
15.9
作者：
Barthas F;Kwan AC
通讯作者：
Kwan AC
DOI：
10.1126/science.aao0862
发表时间：
2018-06-22
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
El-Boustani S;Ip JPK;Breton-Provencher V;Knott GW;Okuno H;Bito H;Sur M
通讯作者：
Sur M
影响因子：
16.2
作者：
Chung JE;Magland JF;Barnett AH;Tolosa VM;Tooker AC;Lee KY;Shah KG;Felix SH;Frank LM;Greengard LF
通讯作者：
Greengard LF
影响因子：
16.2
作者：
Feng, Jiesi;Zhang, Changmei;Li, Yulong
通讯作者：
Li, Yulong