Significantly Improved COVID-19 Outcomes in Countries with Higher BCG Vaccination Coverage: A Multivariable Analysis.
Significantly Improved COVID-19 Outcomes in Countries with Higher BCG Vaccination Coverage: A Multivariable Analysis.
复制标题
DOI：
10.3390/vaccines8030378
复制
发表时间：
2020-07-11
期刊：
影响因子：
7.8
通讯作者：
Linial M
中科院分区：
文献类型：
--
作者：
Klinger D;Blass I;Rappoport N;Linial M
从中国开始的新冠肺炎疫情在3个月内蔓延到全球。我们检验了一种假设，即卡介苗（Bacille calmette - gusamrin vaccine， BCG）接种结核病疫苗与COVID-19患者的更好预后相关。我们的分析涵盖了符合人口规模和百万人死亡人数（DPM）预定阈值的55个国家。我们发现接种卡介苗的年数与DPM与大流行的进展之间存在很强的负相关，排列试验证实了这一点。23项经济、人口统计学、健康相关和大流行限制相关定量特性的多变量回归检验结果证实了BCG年限对COVID-19结局的主要贡献。根据年龄组划分对各国进行的分析显示，相关性最强的是年轻人口（0-24岁）的卡介苗接种覆盖率。此外，在最近15年中，卡介苗覆盖率与卡介苗覆盖率有很强的相关性和统计学意义，但在这些年中，与其他广泛使用的麻疹和风疹疫苗接种方案没有观察到相关性。我们认为，卡介苗免疫覆盖率，特别是在最近接种疫苗的人群中，有助于减弱COVID-19大流行的传播和严重程度。
The COVID-19 pandemic that started in China has spread within 3 months to the entire globe. We tested the hypothesis that the vaccination against tuberculosis by Bacille Calmette–Guérin vaccine (BCG) correlates with a better outcome for COVID-19 patients. Our analysis covers 55 countries complying with predetermined thresholds on the population size and number of deaths per million (DPM). We found a strong negative correlation between the years of BCG administration and the DPM along with the progress of the pandemic, corroborated by permutation tests. The results from multivariable regression tests with 23 economic, demographic, health-related, and pandemic restriction-related quantitative properties, substantiate the dominant contribution of BCG years to the COVID-19 outcomes. The analysis of countries according to an age-group partition reveals that the strongest correlation is attributed to the coverage in BCG vaccination of the young population (0–24 years). Furthermore, a strong correlation and statistical significance are associated with the degree of BCG coverage for the most recent 15 years, but no association was observed in these years for other broadly used vaccination protocols for measles and rubella. We propose that BCG immunization coverage, especially among the most recently vaccinated population, contribute to attenuation of the spread and severity of the COVID-19 pandemic.
登录
查看更多内容
影响因子：
5.4
作者：
Glaziou, Philippe;Sismanidis, Charalambos;Raviglione, Mario
通讯作者：
Raviglione, Mario
影响因子：
11.8
作者：
BREWER, TF;COLDITZ, GA
通讯作者：
COLDITZ, GA
影响因子：
82.9
作者：
Dijkman, Karin;Sombroek, Claudia C.;Verreck, Frank A. W.
通讯作者：
Verreck, Frank A. W.
影响因子：
3.9
作者：
Boldog, Peter;Tekeli, Tamas;Rost, Gergely
通讯作者：
Rost, Gergely
DOI：
10.1073/pnas.2004911117
发表时间：
2020-05-05
影响因子：
11.1
作者：
Dowd, Jennifer Beam;Andriano, Liliana;Mills, Melinda C.
通讯作者：
Mills, Melinda C.