Behaviorally functional opioid systems in infant rats: II. Evidence for pharmacological, physiological, and psychological mediation of pain and stress.
Behaviorally functional opioid systems in infant rats: II. Evidence for pharmacological, physiological, and psychological mediation of pain and stress.
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幼鼠的行为功能性阿片类药物系统：II。
DOI：
10.1037//0735-7044.100.5.624
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发表时间：
1986
影响因子：
1.9
通讯作者：
Blass,EM
中科院分区：
文献类型：
--
作者：
Kehoe,P;Blass,EM
两个实验，与160个10天大的Sprague-Dawley大鼠幼崽，检查了行为特征的新生阿片系统在痛苦的情况下，使用修改的热板爪舔测试。腹腔注射吗啡（0.5mg/kg）后，小鼠出现热痛。皮下注射纳洛酮（0.5 mg/kg）阻止镇痛。吗啡镇痛显着更大的Ss组隔离的大坝。与母兽隔离的盐水对照组表现出比它们的巢居同胞更长的哺乳期。单独隔离5 min可显著延长缩爪潜伏期，且这种作用是纳洛酮可逆的。镇痛没有看到时，直接从巢测试或分组时，与他人5分钟。这表明，阿片类药物系统的压力和疼痛的功能在10天大的大鼠和短期隔离从大坝是一个可能的自然应激源调节内源性阿片类药物的释放。(51参考）（PsycINFO数据库记录（c）2016阿帕，保留所有权利）
Two experiments, with 160 10-day-old Sprague-Dawley rat pups, examined the behavioral characteristics of the neonatal opioid system during distressful situations, using a modification of the hot-plate paw-lick test. Ss were analgesic to heat following intraperitoneal morphine (0.5 mg/kg). Subcutaneous naloxone (0.5 mg/kg) prevented the analgesia. Morphine analgesia was significantly greater in Ss group-isolated from the dam. Saline controls group-isolated from the dam exhibited longer latencies than their nest-housed siblings. Individual isolation for 5 min markedly increased paw-withdrawal latency, and this effect was naltrexone reversible. Analgesia was not seen when Ss were tested directly from the nest or when grouped with others for 5 min. It is suggested that the opioid systems for stress and pain are functional in 10-day-old rats and that short-term isolation from the dam is a probable natural stressor modulated by endogenous opioid release.(51 ref)(PsycINFO Database Record (c) 2016 APA, all rights reserved)
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DOI：
--
发表时间：
1975-03
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
J. O'Callaghan;S. Holtzman
通讯作者：
J. O'Callaghan;S. Holtzman
影响因子：
56.9
作者：
LEWIS, JW;CANNON, JT;LIEBESKIND, JC
通讯作者：
LIEBESKIND, JC
幼鼠的行为功能性阿片类药物系统：I.嗅觉和味觉经典调节的证据。
影响因子：
1.9
作者：
Kehoe,P;Blass,EM
通讯作者：
Blass,EM
应激大鼠释放的气味会在未应激大鼠中产生阿片类镇痛作用。
影响因子：
1.9
作者：
Michael S. Fanselow
通讯作者：
Michael S. Fanselow
影响因子：
2.9
作者：
Gordon A. Barr;Gordon A. Barr;William Paredes;Karen L. Erickson;R. Zukin
通讯作者：
Gordon A. Barr;Gordon A. Barr;William Paredes;Karen L. Erickson;R. Zukin