Enhancement of Bone Regeneration Through the Converse Piezoelectric Effect, A Novel Approach for Applying Mechanical Stimulation.
Enhancement of Bone Regeneration Through the Converse Piezoelectric Effect, A Novel Approach for Applying Mechanical Stimulation.
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应用机械刺激的一种新方法--逆压电效应促进骨再生。
DOI：
10.1089/bioe.2021.0019
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发表时间：
2021-12-01
期刊：
影响因子：
2.3
通讯作者：
Moatti A
中科院分区：
文献类型：
--
作者：
Carter A;Popowski K;Cheng K;Greenbaum A;Ligler FS;Moatti A
严重的骨损伤对患者的生命具有破坏性影响，包括限制工作能力和高昂的费用。骨科植入物可以帮助愈合损伤，其程度超过骨修复骨折或大骨缺损的自然再生能力。自体移植物和同种异体移植物是所使用的标准植入物，但是诸如供体部位并发症、可移植骨的数量有限以及高成本等缺点导致了对合成骨移植替代物的需求增加。然而，复制生物骨的复杂生理特性，更不用说再现其复杂的组织功能，是具有挑战性的。由于骨具有天然的压电特性，设计模拟骨中自然愈合过程的生物相容性植入物的广泛努力导致了对压电智能材料的研究。压电材料通过响应于机械应力而积累电荷（其通过直接压电效应模拟生物电信号）或通过响应于电刺激而通过匡威压电效应提供机械刺激来促进骨再生。虽然这两种效应都是有益的，但匡威的压电效应可以通过改善愈合缺陷的机械响应来解决应力屏蔽和不动性引起的骨萎缩。机械刺激通过激活增加骨形成和减少骨吸收的细胞途径对骨再生产生积极影响。这篇评论将突出的潜力，匡威压电效应，以提高骨再生的讨论激活有益的细胞通路，压电生物材料的性能，和潜在的更有效的管理使用无线控制的匡威压电效应。
Serious bone injuries have devastating effects on the lives of patients including limiting working ability and high cost. Orthopedic implants can aid in healing injuries to an extent that exceeds the natural regenerative capabilities of bone to repair fractures or large bone defects. Autografts and allografts are the standard implants used, but disadvantages such as donor site complications, a limited quantity of transplantable bone, and high costs have led to an increased demand for synthetic bone graft substitutes. However, replicating the complex physiological properties of biological bone, much less recapitulating its complex tissue functions, is challenging. Extensive efforts to design biocompatible implants that mimic the natural healing processes in bone have led to the investigation of piezoelectric smart materials because the bone has natural piezoelectric properties. Piezoelectric materials facilitate bone regeneration either by accumulating electric charge in response to mechanical stress, which mimics bioelectric signals through the direct piezoelectric effect or by providing mechanical stimulation in response to electrical stimulation through the converse piezoelectric effect. Although both effects are beneficial, the converse piezoelectric effect can address bone atrophy from stress shielding and immobility by improving the mechanical response of a healing defect. Mechanical stimulation has a positive impact on bone regeneration by activating cellular pathways that increase bone formation and decrease bone resorption. This review will highlight the potential of the converse piezoelectric effect to enhance bone regeneration by discussing the activation of beneficial cellular pathways, the properties of piezoelectric biomaterials, and the potential for the more effective administration of the converse piezoelectric effect using wireless control.
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影响因子：
3.5
作者：
Bagchi, Amrit;Meka, Sai Rama Krishna;Chatterjee, Kaushik
通讯作者：
Chatterjee, Kaushik
影响因子：
--
作者：
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Tiwari A
DOI：
10.1016/j.bbrc.2004.01.138
发表时间：
2004-03-19
影响因子：
3.1
作者：
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通讯作者：
Klein-Nulend, J
影响因子：
4.6
作者：
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通讯作者：
Hierold, Christofer
DOI：
10.1109/tbcas.2014.2370794
发表时间：
2016-02-01
影响因子：
5.1
作者：
Ahn, Dukju;Ghovanloo, Maysam
通讯作者：
Ghovanloo, Maysam