Microglia Versus Myeloid Cell Nomenclature during Brain Inflammation.
Microglia Versus Myeloid Cell Nomenclature during Brain Inflammation.
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DOI：
10.3389/fimmu.2015.00249
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发表时间：
2015
影响因子：
7.3
通讯作者：
Croxford AL
中科院分区：
文献类型：
--
作者：
Greter M;Lelios I;Croxford AL
作为中枢神经系统（CNS）的免疫哨兵，小胶质细胞不仅对病理条件反应迅速，而且有助于健康大脑的稳态。与骨髓谱系的其他群体相反，成年小胶质细胞来源于胚胎发育早期卵黄囊中出现的原始骨髓前体，之后它们局部自我维持并且独立于血液传播的骨髓前体。在神经炎性病症如实验性自身免疫性脑脊髓炎下，循环单核细胞侵入CNS实质，其中它们进一步分化成巨噬细胞或炎性树突细胞。通常很难使用目前已知的标记物从浸润的髓样细胞中描绘出驻留的小胶质细胞。在这里，我们将讨论目前可靠区分这些人群的方法，以及最近的进展有助于明确表型相似但功能多样的骨髓细胞类型之间的定义。
As immune sentinels of the central nervous system (CNS), microglia not only respond rapidly to pathological conditions but also contribute to homeostasis in the healthy brain. In contrast to other populations of the myeloid lineage, adult microglia derive from primitive myeloid precursors that arise in the yolk sac early during embryonic development, after which they self-maintain locally and independently of blood-borne myeloid precursors. Under neuro-inflammatory conditions such as experimental autoimmune encephalomyelitis, circulating monocytes invade the CNS parenchyma where they further differentiate into macrophages or inflammatory dendritic cells. Often it is difficult to delineate resident microglia from infiltrating myeloid cells using currently known markers. Here, we will discuss the current means to reliably distinguish between these populations, and which recent advances have helped to make clear definitions between phenotypically similar, yet functionally diverse myeloid cell types.
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影响因子：
11.2
作者：
Butovsky, Oleg;Jedrychowski, Mark P.;Cialic, Ron;Krasemann, Susanne;Murugaiyan, Gopal;Fanek, Zain;Greco, David J.;Wu, Pauline M.;Doykan, Camille E.;Kiner, Olga;Lawson, Robert J.;Frosch, Matthew P.;Pochet, Nathalie;El Fatimy, Rachid;Krichevsky, Anna M.;Gygi, Steven P.;Lassmann, Hans;Berry, James;Cudkowicz, Merit E.;Weiner, Howard L.
通讯作者：
Weiner, Howard L.
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
3.1
作者：
Almolda, Beatriz;Gonzalez, Berta;Castellano, Bernardo
通讯作者：
Castellano, Bernardo
影响因子：
64.5
作者：
Gosselin D;Link VM;Romanoski CE;Fonseca GJ;Eichenfield DZ;Spann NJ;Stender JD;Chun HB;Garner H;Geissmann F;Glass CK
通讯作者：
Glass CK
肺泡巨噬细胞从胎儿单核细胞中发展，这些单核细胞在生命的第一周通过GM-CSF分化为长寿命细胞。
DOI：
10.1084/jem.20131199
发表时间：
2013-09-23
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Guilliams M;De Kleer I;Henri S;Post S;Vanhoutte L;De Prijck S;Deswarte K;Malissen B;Hammad H;Lambrecht BN
通讯作者：
Lambrecht BN