Mesenchymal Stem Cells for Cartilage Regeneration of TMJ Osteoarthritis.
Mesenchymal Stem Cells for Cartilage Regeneration of TMJ Osteoarthritis.
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间充质干细胞用于颞下颌关节骨关节炎的软骨再生
DOI：
10.1155/2017/5979741
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发表时间：
2017
影响因子：
4.3
通讯作者：
Zhou Y
中科院分区：
文献类型：
--
作者：
Cui D;Li H;Xu X;Ye L;Zhou X;Zheng L;Zhou Y
颞下颌关节骨关节炎（Temporomandibularjointosteoarthritis，TMJOA）是一种以进行性软骨退化、软骨下骨改建、滑膜炎和慢性疼痛为特征的退行性疾病。由于髁突软骨的自我修复能力有限，传统的临床治疗对修复受损的软骨以及其他TMJ组织的骨修复和结构修复效果有限。近年来，基于干细胞的治疗作为组织修复和再生的替代方法引起了广泛关注。来源于骨髓、滑膜甚至脐带的间充质干细胞（MSC）在TMJ OA的软骨再生中发挥着种子细胞的作用。骨髓间充质干细胞具有多向分化潜能，包括成软骨分化和成骨分化。此外，MSC的营养调节在异常条件下发挥抗炎和免疫调节作用。此外，骨髓间充质干细胞与合适的支架材料结合，可形成软骨甚至骨间室，以修复受损的组织和功能受损的颞下颌关节。本文就颞下颌关节骨性关节炎软骨退变的发病机制进行综述，重点介绍骨髓间充质干细胞的潜在来源和软骨再生的新方法，特别是以骨髓间充质干细胞为基础的治疗和组织工程。
Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease, characterized by progressive cartilage degradation, subchondral bone remodeling, synovitis, and chronic pain. Due to the limited self-healing capacity in condylar cartilage, traditional clinical treatments have limited symptom-modifying and structure-modifying effects to restore impaired cartilage as well as other TMJ tissues. In recent years, stem cell-based therapy has raised much attention as an alternative approach towards tissue repair and regeneration. Mesenchymal stem cells (MSCs), derived from the bone marrow, synovium, and even umbilical cord, play a role as seed cells for the cartilage regeneration of TMJ OA. MSCs possess multilineage differentiation potential, including chondrogenic differentiation as well as osteogenic differentiation. In addition, the trophic modulations of MSCs exert anti-inflammatory and immunomodulatory effects under aberrant conditions. Furthermore, MSCs combined with appropriate scaffolds can form cartilaginous or even osseous compartments to repair damaged tissue and impaired function of TMJ. In this review, we will briefly discuss the pathogenesis of cartilage degeneration in TMJ OA and emphasize the potential sources of MSCs and novel approaches for the cartilage regeneration of TMJ OA, particularly focusing on the MSC-based therapy and tissue engineering.
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影响因子：
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作者：
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作者：
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影响因子：
7
作者：
Cevidanes, L. H. S.;Walker, D.;Schilling, J.;Sugai, J.;Giannobile, W.;Paniagua, B.;Benavides, E.;Zhu, H.;Marron, J. S.;Jung, B. T.;Baranowski, D.;Rhodes, J.;Nackley, A.;Lim, P. F.;Ludlow, J. B.;Nguyen, T.;Goncalves, J. R.;Wolford, L.;Kapila, S.;Styner, M.
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Styner, M.
DOI：
10.1016/j.joms.2011.12.030
发表时间：
2012-11
期刊：
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
影响因子：
--
作者：
Brown BN;Chung WL;Almarza AJ;Pavlick MD;Reppas SN;Ochs MW;Russell AJ;Badylak SF
通讯作者：
Badylak SF
影响因子：
2.6
作者：
Covas, Dimas T.;Panepucci, Rodrigo A.;Zago, Marco A.
通讯作者：
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