3D osteoarthritic changes in TMJ condylar morphology correlates with specific systemic and local biomarkers of disease.
3D osteoarthritic changes in TMJ condylar morphology correlates with specific systemic and local biomarkers of disease.
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TMJ Condylar形态的3D骨关节炎变化与特定的全身和局部疾病生物标志物相关。
DOI：
10.1016/j.joca.2014.06.014
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发表时间：
2014-10
影响因子：
7
通讯作者：
Styner, M.
中科院分区：
文献类型：
--
作者：
Cevidanes, L. H. S.;Walker, D.;Schilling, J.;Sugai, J.;Giannobile, W.;Paniagua, B.;Benavides, E.;Zhu, H.;Marron, J. S.;Jung, B. T.;Baranowski, D.;Rhodes, J.;Nackley, A.;Lim, P. F.;Ludlow, J. B.;Nguyen, T.;Goncalves, J. R.;Wolford, L.;Kapila, S.;Styner, M.
评估诊断为颞下颌关节骨关节炎（tmjoa）的受试者的三维形态学变化和局部和全身生物标志物谱。本研究共招募28例长期TMJ OA患者（39.9±16年）、12例初诊OA患者（47.4±16.1年）和12例健康对照（41.8±12.2年）。所有患者均为女性，均行锥形束CT扫描。对12例骨性关节炎患者和12例年龄匹配的健康对照进行TMJ关节穿刺和静脉穿刺。采用蛋白芯片技术对50种关节炎炎症生物标志物的血清和滑液水平进行定量分析。形状分析MANCOVA测试了生物标志物水平与髁突形态变化之间的统计相关性。与健康对照相比，骨性关节炎的平均髁突除前表面外，在所有尺寸上都明显变小，其区域表明沿关节表面有骨吸收，特别是在外侧极。滑膜液中ANG、GDF15、TIMP-1、CXCL16、MMP-3、MMP-7水平与髁前表面骨对位有显著相关性。血清中ENA-78、MMP-3、PAI-1、VE-Cadherin、VEGF、GM-CSF、tgf - βb1、ifn - γg、tnf - αa、IL-1αa、IL-6水平与侧极扁平化显著相关。在健康对照中，ANG的表达水平与关节形态有显著相关。关节面骨吸收，特别是外侧极骨吸收在TMJ OA的初始诊断中具有统计学意义。滑液中ANG、GDF15、TIMP-1、CXCL16、MMP-3、MMP-7水平与骨附着相关。血清ENA-78、MMP-3、PAI-1、VE-Cadherin、VEGF、GM-CSF、tgf - β1、IFNγ、TNFα、IL-1α、IL-6水平与骨吸收相关。
To assess 3D morphological variations and local and systemic biomarker profiles in subjects with a diagnosis of temporomandibular joint osteoarthritis (TMJ OA). Twenty-eight patients with long-term TMJ OA (39.9 ± 16 years), 12 patients at initial diagnosis of OA (47.4 ± 16.1 years), and 12 healthy controls (41.8 ± 12.2 years) were recruited. All patients were female and had cone beam CT scans taken. TMJ arthrocentesis and venipuncture were performed on 12 OA and 12 age-matched healthy controls. Serum and synovial fluid levels of 50 biomarkers of arthritic inflammation were quantified by protein microarrays. Shape Analysis MANCOVA tested statistical correlations between biomarker levels and variations in condylar morphology. Compared with healthy controls, the OA average condyle was significantly smaller in all dimensions except its anterior surface, with areas indicative of bone resorption along the articular surface, particularly in the lateral pole. Synovial fluid levels of ANG, GDF15, TIMP-1, CXCL16, MMP-3 and MMP-7 were significantly correlated with bone apposition of the condylar anterior surface. Serum levels of ENA-78, MMP-3, PAI-1, VE-Cadherin, VEGF, GM-CSF, TGFβb1, IFNγg, TNFαa, IL-1αa, and IL-6 were significantly correlated with flattening of the lateral pole. Expression levels of ANG were significantly correlated with the articular morphology in healthy controls. Bone resorption at the articular surface, particularly at the lateral pole was statistically significant at initial diagnosis of TMJ OA. Synovial fluid levels of ANG, GDF15, TIMP-1, CXCL16, MMP-3 and MMP-7 were correlated with bone apposition. Serum levels of ENA-78, MMP-3, PAI-1, VE-Cadherin, VEGF, GM-CSF, TGFβ1, IFNγ, TNFα, IL-1α, and IL-6 were correlated with bone resorption.
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影响因子：
1.9
作者：
Alstergren, P;Ernberg, M;Kopp, S
通讯作者：
Kopp, S
影响因子：
4.9
作者：
Dam EB;Loog M;Christiansen C;Byrjalsen I;Folkesson J;Nielsen M;Qazi AA;Pettersen PC;Garnero P;Karsdal MA
通讯作者：
Karsdal MA
DOI：
10.1016/j.tripleo.2010.01.008
发表时间：
2010-07
期刊：
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
影响因子：
--
作者：
Cevidanes LH;Hajati AK;Paniagua B;Lim PF;Walker DG;Palconet G;Nackley AG;Styner M;Ludlow JB;Zhu H;Phillips C
通讯作者：
Phillips C
影响因子：
1.9
作者：
Alstergren, P;Kopp, S
通讯作者：
Kopp, S
DOI：
10.1038/ncprheum0508
发表时间：
2007-06-01
期刊：
NATURE CLINICAL PRACTICE RHEUMATOLOGY
影响因子：
--
作者：
Rousseau, Jean-Charles;Delmas, Pierre D.
通讯作者：
Delmas, Pierre D.