Gold Nanorods with Silica Shell and PAMAM Dendrimers for Efficient Photothermal Therapy and Low Toxic Codelivery of Anticancer Drug and siRNA
Gold Nanorods with Silica Shell and PAMAM Dendrimers for Efficient Photothermal Therapy and Low Toxic Codelivery of Anticancer Drug and siRNA
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具有二氧化硅壳和 PAMAM 树枝状聚合物的金纳米棒可实现高效光热治疗以及抗癌药物和 siRNA 的低毒共递送
DOI：
10.1002/admi.201701166
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发表时间：
2017-11
影响因子：
5.4
通讯作者：
刘遵峰
中科院分区：
文献类型：
--
作者：
Qianyu Zhang;Li Wang;Yajun Jiang;Wei Gao;王银松;杨晓英;杨新林;刘遵峰
具有嫁接的多胺树状聚合物（G3）的多功能纳米复合材料通过发散技术生长在中孔硅涂层的金纳米棒（Aunrs@sio2）的表面上。最终的Aunrs@Sio2-G3纳米复合材料具有均匀尺寸和出色的稳定性，不仅可以用作靶向对比度。癌症治疗的效率。在较低的pH条件和近红外激光照射下，来自aunrs@sio2-G3纳米复合材料的受控阿霉素（DOX）。将Bcl-2靶向。将siRNA转染到肿瘤细胞中，并诱导蛋白质表达的敲低，这是通过蛋白质印迹测定确认的。此外，MTT分析证明了化学和基因治疗对MCF-7细胞改善光热治疗的互补作用。 DOX和siRNA加工的Aunrs@SiO2-G3纳米复合材料显示出对DOX的细胞毒性的较低，导致对正常组织的毒性低。多功能纳米复合材料具有潜在的应用，作为纳米植物形式，可以将光热化学肿瘤疗法与高效率相结合。
The multifunctional nanocomposites with grafting polyamidoamine dendrimers up to third generation (G3) are grown onto the surface of mesoporous silica-coated gold nanorods (AuNRs@SiO2) via a divergent technique. The resultant AuNRs@SiO2-G3 nanocomposites with uniform size and excellent stability not only enable their utilization as targeted contrast.agents for photothermal cancer therapy but also serve as scaffolds for the.intracellular delivery of anticancer drug and small interfering RNA (siRNA) to enhance the efficiency of cancer therapy. The controlled doxorubicin (DOX).release from AuNRs@SiO2-G3 nanocomposites is significantly improved under lower pH condition and near-infrared laser irradiation. The Bcl-2-targeted.siRNA is transfected into tumor cells and induces knockdown of the protein expression, which is confirmed by western blot assays. Furthermore, the complementary effect of chemo- and gene therapy to MCF-7 cells for improved photothermal therapy is demonstrated by MTT assay. The DOX and siRNA coloaded AuNRs@SiO2-G3 nanocomposites show much lower cytotoxicity.compared to the DOX, resulting in low toxicity to normal tissues. The multifunctional nanocomposites have potential application as nanoplatforms to integrate the photothermal-chemo-gene tumor therapy with high efficiency.
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DOI：
10.1016/j.jconrel.2014.09.026
发表时间：
2014-12
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Feihu Wang;Yuanyuan Shen;Wenjun Zhang;Min Li;Yun Wang;Dejian Zhou;Shengrong Guo
通讯作者：
Feihu Wang;Yuanyuan Shen;Wenjun Zhang;Min Li;Yun Wang;Dejian Zhou;Shengrong Guo
影响因子：
41.2
作者：
Conde J;Oliva N;Zhang Y;Artzi N
通讯作者：
Artzi N
快速清除纳米载体进行化疗/光热联合疗法抑制恶性肿瘤复发
影响因子：
13.3
作者：
Zhao Lingzhi;Yuan Wei;Huijun Phoebe Tham;Chen Hongzhong;Xing Pengyao;Xiang Huijing;Yao Xin;Qiu Xiaochen;Dai Yu;Zhu Liangliang;Li Fuyou;Zhao Yanli
通讯作者：
Zhao Yanli
影响因子：
9.5
作者：
Anna Li Volsi;C. Scialabba;V. Vetri;G. Cavallaro;M. Licciardi;G. Giammona
通讯作者：
Anna Li Volsi;C. Scialabba;V. Vetri;G. Cavallaro;M. Licciardi;G. Giammona
影响因子：
8.6
作者：
B. Nikoobakht;A. El-SayedM
通讯作者：
B. Nikoobakht;A. El-SayedM