Monounsaturated fatty acids prevent the aversive effects of obesity on locomotion, brain activity, and sleep behavior.
Monounsaturated fatty acids prevent the aversive effects of obesity on locomotion, brain activity, and sleep behavior.
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DOI：
10.2337/db11-1521
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发表时间：
2012-07
期刊：
影响因子：
7.7
通讯作者：
Hennige AM
中科院分区：
文献类型：
--
作者：
Sartorius T;Ketterer C;Kullmann S;Balzer M;Rotermund C;Binder S;Hallschmid M;Machann J;Schick F;Somoza V;Preissl H;Fritsche A;Häring HU;Hennige AM
脂肪和缺乏运动是肥胖症发病机制中最明显的因素，脂肪质量似乎对葡萄糖稳态的测量起着至关重要的作用。然而，膳食脂肪质量对大脑功能，行为和睡眠的影响基本上是未知的。在这项研究中，给小鼠喂食补充单不饱和脂肪酸（MUFA）或饱和脂肪酸（SFA）的饮食，并评估其对葡萄糖稳态、运动、大脑活动和睡眠行为的影响。MUFA和SFA导致脂肪量显著增加，但仅喂食SFA伴随小鼠葡萄糖耐受不良。无线电遥测显示，SFA小鼠的皮质活动显着减少，而MUFA甚至改善了活动。SFA减少觉醒，增加非快速眼动睡眠。脑室内应用胰岛素促进了MUFA喂养小鼠的自发活动，而SFA小鼠则具有抵抗性。在人类中，富含SFA的饮食导致海马和皮质活动减少，这是通过功能性磁共振成像技术确定的。总之，膳食摄入MUFA促进了大脑中的胰岛素作用，其对皮质活动，运动和睡眠的有益作用，而相当的SFA摄入量在小鼠和人类中作为大脑活动的负调节剂。
Fat and physical inactivity are the most evident factors in the pathogenesis of obesity, and fat quality seems to play a crucial role for measures of glucose homeostasis. However, the impact of dietary fat quality on brain function, behavior, and sleep is basically unknown. In this study, mice were fed a diet supplemented with either monounsaturated fatty acids (MUFAs) or saturated fatty acids (SFAs) and their impact on glucose homeostasis, locomotion, brain activity, and sleep behavior was evaluated. MUFAs and SFAs led to a significant increase in fat mass but only feeding of SFAs was accompanied by glucose intolerance in mice. Radiotelemetry revealed a significant decrease in cortical activity in SFA-mice whereas MUFAs even improved activity. SFAs decreased wakefulness and increased non–rapid eye movement sleep. An intracerebroventricular application of insulin promoted locomotor activity in MUFA-fed mice, whereas SFA-mice were resistant. In humans, SFA-enriched diet led to a decrease in hippocampal and cortical activity determined by functional magnetic resonance imaging techniques. Together, dietary intake of MUFAs promoted insulin action in the brain with its beneficial effects for cortical activity, locomotion, and sleep, whereas a comparable intake of SFAs acted as a negative modulator of brain activity in mice and humans.
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影响因子：
9.8
作者：
Ropelle, Eduardo R.;Flores, Marcelo B.;Carvalheira, Jose B. C.
通讯作者：
Carvalheira, Jose B. C.
影响因子：
4.4
作者：
Machann, J;Thamer, C;Schick, F
通讯作者：
Schick, F
影响因子：
4.2
作者：
SHIMOMURA, Y;TAMURA, T;SUZUKI, M
通讯作者：
SUZUKI, M
影响因子：
15.9
作者：
Hennige, AM;Burks, DJ;White, MF
通讯作者：
White, MF
影响因子：
8.2
作者：
Chaput, J.-P.;Despres, J.-P.;Tremblay, A.
通讯作者：
Tremblay, A.