Metabolic syndrome and onset of depressive symptoms in the elderly: findings from the three-city study.
Metabolic syndrome and onset of depressive symptoms in the elderly: findings from the three-city study.
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DOI：
10.2337/dc10-1644
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发表时间：
2011-04
期刊：
影响因子：
16.2
通讯作者：
Ritchie K
中科院分区：
文献类型：
--
作者：
Akbaraly TN;Ancelin ML;Jaussent I;Ritchie C;Barberger-Gateau P;Dufouil C;Kivimaki M;Berr C;Ritchie K
鉴于老年人代谢综合征（MetS）和抑郁症状的患病率不断增加，我们的目的是前瞻性地研究MetS和抑郁症状发作之间的关联，根据不同的年龄组在一个大的，一般的老年人口。这是一项前瞻性队列研究，共有4,446名年龄在65-91岁之间的男性和女性参与，他们在基线时没有抑郁症或抑郁症状（三城市研究，法国）。MetS的定义采用国家胆固醇教育计划成人治疗组III标准。在2年和4年随访时评估新发抑郁症状（流行病学研究中心抑郁量表评分≥16和使用抗抑郁药治疗）。在调整了大范围的潜在混杂因素后，我们观察到MetS与最年轻年龄组（基线时65-70岁）新发抑郁症状的1.73倍（95%CI 1.02-2.95）比值相关，与心血管疾病无关。在年龄较大的人群中没有发现这种联系。我们的研究结果表明，代谢综合征和抑郁症状之间的联系，直到现在证明在中年人可以扩展到老年人，但不是最古老的。需要进一步的研究来检查是否更好地管理MetS可以预防65-70岁人群的抑郁症状。
Given the increasing prevalence of both metabolic syndrome (MetS) and depressive symptoms during old age, we aimed to examine prospectively the association between MetS and the onset of depressive symptoms according to different age-groups in a large, general elderly population. This was a prospective cohort study of 4,446 men and women aged 65–91 years who were free of depression or depressive symptoms at baseline (the Three-City Study, France). MetS was defined using the National Cholesterol Education Program Adult Treatment Panel III criteria. New onset of depressive symptoms (the Center for Epidemiologic Studies Depression Scale score ≥16 and use of antidepressant treatment) was assessed at 2- and 4-year follow-ups. After adjusting for a large range of potential confounders, we observed MetS to be associated with 1.73-fold (95% CI 1.02–2.95) odds for new-onset depressive symptoms in the youngest age-group (65–70 years at baseline), independently of cardiovascular diseases. No such association was seen in older age-groups. Our findings suggest that the link between MetS and depressive symptoms evidenced until now in middle-aged people can be extended to older adults but not to the oldest ones. Additional research is needed to examine if a better management of MetS prevents depressive symptoms in people aged 65–70 years.
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