Mucinous carcinoma of the breast in comparison with invasive ductal carcinoma: clinicopathologic characteristics and prognosis.
Mucinous carcinoma of the breast in comparison with invasive ductal carcinoma: clinicopathologic characteristics and prognosis.
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DOI：
10.4048/jbc.2011.14.4.308
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发表时间：
2011-12
影响因子：
2.4
通讯作者：
Yang JH
中科院分区：
文献类型：
--
作者：
Bae SY;Choi MY;Cho DH;Lee JE;Nam SJ;Yang JH
摘要乳腺粘液癌是一种罕见的乳腺肿瘤。本研究的目的是评估MC的长期无病生存期（DFS）和总生存期（OS）。我们对1994年至2010年数据库中报告的所有MC病例进行了回顾性分析。回顾了268例MC病例的临床病理特征和生存率，并与2455例浸润性导管癌（IDC-NOS）病例进行了比较。与IDC-NOS病例相比，MC病例年龄更小，淋巴结较少，分期较低，激素受体表达较多，HER2过表达较少。MC的5年DFS为95.2%，而IDC-NOS为92.0%。MC的5年OS率为98.9%，而IDC-NOS为94.9%。Cox回归多因素分析显示，黏液类型是低淋巴结状态（N期）和激素治疗的DFS的重要预后因素。对于OS，只有N期是最重要的预后因素，其次是辅助化疗和辅助激素治疗。MC比IDC-NOS具有更好的DFS，但其OS相似。淋巴结状态和辅助治疗似乎比组织学亚型更能预测预后。
Mucinous carcinoma (MC) of the breast is a rare histologic type of mammary neoplasm. The objective of this study was to evaluate the long-term disease-free survival (DFS) and overall survival (OS) of MC. We conducted a retrospective analysis of all MC cases reported to a database between 1994 and 2010. Clinicopathological characteristics and survival of 268 MC cases were reviewed and compared with 2,455 invasive ductal carcinoma-not otherwise specified (IDC-NOS) cases. The MC cases were of a younger age, involved less lymph nodes, lower stage, more expression of hormonal receptors, and less HER2 overexpression compared to the IDC-NOS cases. The 5-year DFS rate for MC was 95.2% compared to 92.0% for IDC-NOS. The 5-year OS rate for MC was 98.9% compared to 94.9% for IDC-NOS. Multivariate analysis using Cox regression revealed that the mucinous type was a significant prognostic factor for DFS with lower nodal status (N stage) and hormonal therapy. For OS, only N stage was the most significant prognostic factor followed by adjuvant chemotherapy and adjuvant hormonal therapy. MC was shown to be associated with a better DFS than IDC-NOS, but it had a similar OS. Nodal status and adjuvant therapy appear to be more significant predictors of prognosis than histologic subtype.
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影响因子：
4.5
作者：
Park S;Koo J;Kim JH;Yang WI;Park BW;Lee KS
通讯作者：
Lee KS
影响因子：
6.4
作者：
Minami, Y;Tsubono, Y;Hisamichi, S
通讯作者：
Hisamichi, S
影响因子：
2.5
作者：
ROSEN, PP;LESSER, ML;KINNE, DW
通讯作者：
KINNE, DW
影响因子：
7.3
作者：
Lacroix-Triki, Magali;Suarez, Paula H.;Reis-Filho, Jorge S.
通讯作者：
Reis-Filho, Jorge S.
影响因子：
3.5
作者：
RASMUSSEN, BB;ROSE, C;CHRISTENSEN, I
通讯作者：
CHRISTENSEN, I