Modulating adult neurogenesis affects synaptic plasticity and cognitive functions in mouse models of Alzheimer's disease.
Modulating adult neurogenesis affects synaptic plasticity and cognitive functions in mouse models of Alzheimer's disease.
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调节成年神经发生影响阿尔茨海默病小鼠模型的突触可塑性和认知功能
DOI：
10.1016/j.stemcr.2021.11.003
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发表时间：
2021-12-14
影响因子：
5.9
通讯作者：
Sun B
中科院分区：
文献类型：
--
作者：
Zhang X;Wei X;Mei Y;Wang D;Wang J;Zhang Y;Li X;Gu Y;Peng G;Sun B
阿尔茨海默病（AD）小鼠模型成年海马区新生神经元异常。调节成人神经发生对AD发病机制的影响因研究而异。我们最近报道了成年神经干细胞（aNSCs）的消融与AD模型记忆力的改善有关。在这里，我们发现，长时程增强（LTP）的APP/PS1小鼠的海马消融后的aNSCs的改善。这种效应在hAPP-J20小鼠（第二种AD小鼠模型）中得到证实。另一方面，我们发现暴露于丰富的环境（EE）显着增加DCX+神经元的数量，促进树突状细胞的生长，并影响新生神经元在APP/PS1小鼠的齿状回的位置，EE暴露显着改善APP/PS1小鼠的记忆缺陷。总之，我们的数据表明，抑制异常的成人神经发生和增强健康的成人神经发生都可能对AD有益，并且它们并不相互排斥。消融aNSC改善AD小鼠海马突触可塑性消融aNSC导致AD小鼠海马重塑EE加速AD小鼠新神经元的发育并改善认知抑制和增强AHN对AD的作用不是相互排斥的在本研究中，Sun和他的同事表明，成年神经干细胞（aNSCs）的消融改善了阿尔茨海默病（AD）小鼠模型中海马突触的可塑性。这种效应与海马的重塑有关。此外，他们的数据表明，抑制和增强成年海马神经发生（AHN）对AD发病机制的影响并不相互排斥。
New neurons are abnormal in the adult hippocampus of Alzheimer's disease (AD) mouse models. The effects of modulating adult neurogenesis on AD pathogenesis differ from study to study. We reported recently that ablation of adult neural stem cells (aNSCs) was associated with improved memory in AD models. Here, we found that long-term potentiation (LTP) was improved in the hippocampus of APP/PS1 mice after ablation of aNSCs. This effect was confirmed in hAPP-J20 mice, a second AD mouse model. On the other hand, we found that exposure to enriched environment (EE) dramatically increased the number of DCX+ neurons, promoted dendritic growth, and affected the location of newborn neurons in the dentate gyrus of APP/PS1 mice, and EE exposure significantly ameliorated memory deficits in APP/PS1 mice. Together, our data suggest that both inhibiting abnormal adult neurogenesis and enhancing healthy adult neurogenesis could be beneficial for AD, and they are not mutually exclusive. Ablation of aNSCs improves hippocampal synaptic plasticity in AD mice Ablation of aNSCs results in hippocampal remodeling in AD mice EE accelerates development of new neurons and improves cognition in AD mice Effects of inhibiting and enhancing AHN on AD are not mutually exclusive In this study, Sun and colleagues show that ablation of adult neural stem cells (aNSCs) improves hippocampal synaptic plasticity in mouse models of Alzheimer's disease (AD). This effect is associated with the remodeling in the hippocampus. Furthermore, their data indicate that effects of inhibiting and enhancing adult hippocampal neurogenesis (AHN) on AD pathogenesis are not mutually exclusive.
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影响因子：
82.9
作者：
Eriksson, PS;Perfilieva, E;Gage, FH
通讯作者：
Gage, FH
影响因子：
5.9
作者：
Babcock KR;Page JS;Fallon JR;Webb AE
通讯作者：
Webb AE
影响因子：
3.3
作者：
Hörtnagl H;Tasan RO;Wieselthaler A;Kirchmair E;Sieghart W;Sperk G
通讯作者：
Sperk G
DOI：
10.1073/pnas.1206171109
发表时间：
2012-05-29
影响因子：
11.1
作者：
Busche, Marc Aurel;Chen, Xiaowei;Konnerth, Arthur
通讯作者：
Konnerth, Arthur
影响因子：
4.7
作者：
Kwakowsky, Andrea;Guzman, Beatriz Calvo-Flores;Faull, Richard L.
通讯作者：
Faull, Richard L.