Associations of equol-producing status with white matter lesion and amyloid-β deposition in cognitively normal elderly Japanese.
Associations of equol-producing status with white matter lesion and amyloid-β deposition in cognitively normal elderly Japanese.
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DOI：
10.1002/trc2.12089
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Cui C
中科院分区：
文献类型：
--
作者：
Sekikawa A;Higashiyama A;Lopresti BJ;Ihara M;Aizenstein H;Watanabe M;Chang Y;Kakuta C;Yu Z;Mathis C;Kokubo Y;Klunk W;Lopez OL;Kuller LH;Miyamoto Y;Cui C
雌马酚是一种由肠道微生物转化的大豆蛋白的代谢产物，具有抗氧化和抗淀粉样蛋白生成作用。我们评估了雌马酚与白色病变（标准化为总脑体积（WML%））和淀粉样蛋白β（Aβ）沉积的相关性。从2016年到2018年，91名年龄在75岁到89岁之间的认知正常的日本老年人接受了使用11 C-匹兹堡化合物B的脑磁共振成像和正电子发射断层扫描。使用2008年至2012年储存的样本测量血清雌马酚。雌马酚生产者被定义为血清水平>0.生产者进一步分为高（>中位数）和低（≤中位数）生产者。中位数（四分位距）WML%为1.10（0.59 - 1.61）; 24.2%为Aβ阳性，51%为雌马酚产生者。雌马酚生产状态（非生产者，低和高）与WML%显著负相关：分别为1.19，0.89和0.58（趋势P < .01）。雌马酚生成状态与Aβ状态无关。一项针对WML体积的雌马酚随机对照试验是必要的。
Equol, a metabolite of a soy isoflavone transformed by the gut microbiome, is anti‐oxidant and anti‐amyloidogenic. We assessed the associations of equol with white matter lesion normalized to total brain volume (WML%) and amyloid beta (Aβ) deposition. From 2016 to 2018, 91 cognitively normal elderly Japanese aged 75 to 89 underwent brain magnetic resonance imaging and positron emission tomography using 11C‐Pittsburgh compound‐B. Serum equol was measured using stored samples from 2008 to 2012. Equol producers were defined as individuals with serum levels >0. Producers were further divided into high (> the median) and low (≤ the median) producers. The median (interquartile range) WML% was 1.10 (0.59 to 1.61); 24.2% were Aβ positive, and 51% were equol producers. Equol‐producing status (non‐producers, low and high) was significantly inversely associated with WML%: 1.19, 0.89, and 0.58, respectively (trend P < .01). Equol‐producing status was not associated with Aβ status. A randomized‐controlled trial of equol targeting WML volume is warranted.
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影响因子：
9.9
作者：
Henderson, V. W.;St John, J. A.;Mack, W. J.
通讯作者：
Mack, W. J.
影响因子：
--
作者：
Lopez, OL;Jagust, WJ;Kuller, LH
通讯作者：
Kuller, LH
影响因子：
3.2
作者：
Frankenfeld, CL;Atkinson, C;Lampe, JW
通讯作者：
Lampe, JW
影响因子：
5.9
作者：
Messina M
通讯作者：
Messina M
DOI：
10.1093/gerona/63.11.1193
发表时间：
2008-11-01
影响因子：
5.1
作者：
Dodge, Hiroko H.;Kita, Yoshikuni;Ueshima, Hirotsugu
通讯作者：
Ueshima, Hirotsugu