Cardiac aging and insulin resistance: could insulin/insulin-like growth factor (IGF) signaling be used as a therapeutic target?
Cardiac aging and insulin resistance: could insulin/insulin-like growth factor (IGF) signaling be used as a therapeutic target?
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DOI：
10.2174/1381612811319320004
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发表时间：
2013
影响因子：
3.1
通讯作者：
Boudina S
中科院分区：
文献类型：
--
作者：
Boudina S
Intrinsic cardiac aging is an independent risk factor for cardiovascular disease and is associated with structural and functional changes that impede cardiac responses to stress and to cardio-protective mechanisms. Although systemic insulin resistance and the associated risk factors exacerbate cardiac aging, cardiac-specific insulin resistance without confounding systemic alterations, could prevent cardiac aging. Thus, strategies aimed to reduce insulin/insulin-like growth factor (IGF) signaling in the heart prevent cardiac aging in lower organisms and in mammals but the mechanisms underlying this protection are not fully understood. In this review, we describe the impact of aging on the cardiovascular system and discuss the mounting evidence that reduced insulin/IGF signaling in the heart could alleviate age-associated alterations and preserve cardiac performance.
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影响因子：
20.1
作者：
Dai DF;Rabinovitch PS;Ungvari Z
通讯作者：
Ungvari Z
DOI：
10.3724/sp.j.1263.2011.00159
发表时间：
2011-09
期刊：
Journal of geriatric cardiology : JGC
影响因子：
--
作者：
Chaudhary KR;El-Sikhry H;Seubert JM
通讯作者：
Seubert JM
影响因子：
14.9
作者：
CORTOPASSI, GA;ARNHEIM, N
通讯作者：
ARNHEIM, N
影响因子：
2.8
作者：
BENJAMIN, EJ;LEVY, D;SUTTON, MS
通讯作者：
SUTTON, MS
影响因子：
4.8
作者：
Chen, Q;Vazquez, EJ;Lesnefsky, EJ
通讯作者：
Lesnefsky, EJ