Association of physical activity levels and brain white matter in older Latino adults.
Association of physical activity levels and brain white matter in older Latino adults.
复制标题
年龄较大的拉丁裔成年人体育锻炼水平和脑白质的关联。
DOI：
10.1080/13557858.2021.1913484
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发表时间：
2022-10
影响因子：
3.1
通讯作者：
Marquez DX
中科院分区：
文献类型：
--
作者：
Balbim GM;Erickson KI;Ajilore OA;Aguiñaga S;Bustamante EE;Lamar M;Marquez DX
Investigate the associations between self-reported physical activity (PA) engagement and white matter (WM) health (i.e., volume, integrity, and hyperintensities) in older Latinos. Design: Cross-sectional study with community-dwelling older adults from predominantly Latino neighborhoods. Thirty-four cognitively healthy older Latinos from two different cohorts. Participants self-reported demographic information, PA engagement [Community Healthy Activities Model Program for Seniors (CHAMPS) Physical Activity Questionnaire for Older Adults] and magnetic resonance imaging (MRI). We used high-resolution three-dimensional T1- and T2-FLAIR weighted images and diffusion tensor imaging acquired via 3T MRI. We performed a series of hierarchical linear regression models with the addition of relevant covariates to examine the associations between self-reported PA levels and WM volume, integrity, and hyperintensities (separately). We adjusted p-values with the use of the Benjamini-Hochberg's false discovery rate procedure. Higher reported levels of leisure-time moderate-to-vigorous PA were significantly associated with higher WM volume of the posterior cingulate (β = 0.220, SE = 0.125, 95% CI 0.009–0.431, p = 0.047) and isthmus cingulate (β = 0.212, SE = 0.110, 95% CI 0.001–0.443, p = 0.044) after controlling for intracranial volume. Higher levels of total PA were significantly associated with higher overall WM volume of these same regions (posterior cingulate: β = 0.220, SE = 0.125,CI 0.024–0.421, p = 0.046; isthmus cingulate:β = 0.220, SE = 0.125, 95% CI 0.003–0.393; p = 0.040). Significant p-values did not withstand Benjamini-Hochberg’s adjustment. PA was not significantly associated with WM integrity or WM hyperintensities. Higher levels of PA, particularly higher leisure-time moderate-to-vigorous PA, might be associated with greater WM volume in select white matter regions key to brain network integration for physical and cognitive functioning in older Latinos. More research is needed to further confirm these associations.
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DOI：
10.1016/j.trci.2018.08.009
发表时间：
2018
期刊：
Alzheimer's & dementia (New York, N. Y.)
影响因子：
--
作者：
Chen C;Zissimopoulos JM
通讯作者：
Zissimopoulos JM
DOI：
10.1136/bmj.c3666
发表时间：
2010-07-26
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Debette S;Markus HS
通讯作者：
Markus HS
影响因子：
3.7
作者：
Burzynska, Agnieszka Zofia;Chaddock-Heyman, Laura;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
影响因子：
4.1
作者：
Fjell, Anders M.;Walhovd, Kristine B.
通讯作者：
Walhovd, Kristine B.
影响因子：
5.7
作者：
Boots, Elizabeth A.;Zhan, Liang;Lamar, Melissa
通讯作者：
Lamar, Melissa