Distinct fronto-striatal couplings reveal the double-faced nature of response-outcome relations in instruction-based learning.
Distinct fronto-striatal couplings reveal the double-faced nature of response-outcome relations in instruction-based learning.
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DOI：
10.3758/s13415-014-0325-4
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发表时间：
2015-06
期刊：
影响因子：
--
通讯作者：
Wolfensteller U
中科院分区：
文献类型：
--
作者：
Ruge H;Wolfensteller U
高等物种通常通过回顾性地评估行动是否产生了理想的结果来学习新的行为。通过依赖明确的行为指令，只有人类才能使用一种习得捷径，这种捷径前瞻性地指定如何在适当的刺激条件下产生预期的结果。一个最近的和大部分未被探索的假设表明，纹状体区与外侧前额叶皮层（LPFC）时，新的行为是通过明确的指令学习，区域亚专业化存在的差异反应结果的突发事件到当前的任务模型的整合。在行为上，基于学习的结果整合已被链接到功能上不同的性能指标。这包括（1）相容性效应，在学习后测试程序中测量，探索结果-反应（O-R）关联的编码强度，以及（2）在学习过程中增加反应减慢，这表明积极使用O-R关联来在线控制目标导向行动。在目前的功能磁共振成像研究中，我们研究了这些行为指标和动态的额-纹状体耦合之间的相关性，以相互约束和完善的解释神经和行为的措施在可分离的子过程中的结果整合。我们发现O-R编码强度与LPFC-壳核偶联相关，表明壳核与S-R习惯和习惯样O-R关联的形成有关。相比之下，反应减慢作为一个假定的指标，积极使用O-R协会与LPFC尾状核耦合。这一发现突出了相关的尾状核的在线控制目标导向的行动，也在基于预防的学习条件下，并反过来澄清了行为减缓效应的功能相关性。本文的在线版本（doi：10.3758/s13415-014-0325-4）包含补充材料，可供授权用户使用。
Higher species commonly learn novel behaviors by evaluating retrospectively whether actions have yielded desirable outcomes. By relying on explicit behavioral instructions, only humans can use an acquisition shortcut that prospectively specifies how to yield intended outcomes under the appropriate stimulus conditions. A recent and largely unexplored hypothesis suggests that striatal areas interact with lateral prefrontal cortex (LPFC) when novel behaviors are learned via explicit instruction, and that regional subspecialization exists for the integration of differential response–outcome contingencies into the current task model. Behaviorally, outcome integration during instruction-based learning has been linked to functionally distinct performance indices. This includes (1) compatibility effects, measured in a postlearning test procedure probing the encoding strength of outcome–response (O–R) associations, and (2) increasing response slowing across learning, putatively indicating active usage of O–R associations for the online control of goal-directed action. In the present fMRI study, we examined correlations between these behavioral indices and the dynamics of fronto-striatal couplings in order to mutually constrain and refine the interpretation of neural and behavioral measures in terms of separable subprocesses during outcome integration. We found that O–R encoding strength correlated with LPFC–putamen coupling, suggesting that the putamen is relevant for the formation of both S–R habits and habit-like O–R associations. By contrast, response slowing as a putative index of active usage of O–R associations correlated with LPFC–caudate coupling. This finding highlights the relevance of the caudate for the online control of goal-directed action also under instruction-based learning conditions, and in turn clarifies the functional relevance of the behavioral slowing effect. The online version of this article (doi:10.3758/s13415-014-0325-4) contains supplementary material, which is available to authorized users.
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DOI：
10.1196/annals.1390.006
发表时间：
2007-01-01
期刊：
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影响因子：
--
作者：
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影响因子：
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作者：
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DOI：
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发表时间：
2001-02-01
影响因子：
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