Categorical analysis of the impact of aerobic and resistance exercise training, alone and in combination, on cardiorespiratory fitness levels in patients with type 2 diabetes: results from the HART-D study.
Categorical analysis of the impact of aerobic and resistance exercise training, alone and in combination, on cardiorespiratory fitness levels in patients with type 2 diabetes: results from the HART-D study.
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DOI：
10.2337/dc12-2194
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发表时间：
2013-10
期刊：
影响因子：
16.2
通讯作者：
Church TS
中科院分区：
文献类型：
--
作者：
Johannsen NM;Swift DL;Lavie CJ;Earnest CP;Blair SN;Church TS
低心肺适合度(CRF)是心血管疾病(CVD)的独立危险因素，尤其是在患有2型糖尿病的人中。已经制定了年龄预测、性别分层和最大MET切点，以确定低CRF类别的心血管事件和死亡率的风险。在9个月的有氧训练(AT)、阻力训练(RT)或两者结合(ATRT)之前和之后，我们研究了超过这些临界点的2型糖尿病(HART-D)参与者有氧训练和阻力训练对健康有益的比例。来自HART-D研究(n=196)的参与者在2007年4月至2009年8月期间被随机分配到运动训练(AT、RT或ATRT)或非运动控制组，用于这项辅助研究。以前为年龄预测的METS(分别为100%和85%，平均和增加的心血管疾病风险)、年龄和性别分层的METS(有氧中心纵向研究)和临床可辨别的METS(男性8.0，女性6.5)设定了分界点。在所有干预组中，超过这些临界点的参与者的基线患病率相似(P&>0.50)，范围从11.9%(预测的100%年龄)到55.1%(预测的85%的年龄)。在AT和ATRT后，基线患病率以及年龄、性别和种族/民族调整的参与者在每个临界点以上的百分比显著增加(均P<；0.05)。有组织的运动训练，特别是AT部分，与更多的参与者超过表明低CRF的既定临界点有关。这些结果对越来越多的患有心血管疾病高危的2型糖尿病患者具有公共卫生和临床意义。
Low cardiorespiratory fitness (CRF) is an independent risk factor for cardiovascular disease (CVD), especially in individuals with type 2 diabetes. Age-predicted, sex-stratified, and maximal MET cut points have been developed to determine the risk of CVD events and mortality in low CRF categories. We examined the proportion of Health Benefits of Aerobic and Resistance Training in Individuals With Type 2 Diabetes (HART-D) participants above these cut points before and after 9 months of aerobic training (AT), resistance training (RT), or a combination of both (ATRT). Participants from the HART-D study (n = 196) who were randomly assigned to exercise training (AT, RT, or ATRT) or to a nonexercise control group between April 2007 and August 2009 were used in this ancillary study. Cut points were previously established for age-predicted METs (>100% and >85%, mean and increased CVD risk, respectively), age- and sex-stratified METs (Aerobic Center Longitudinal Study), and clinically discernible METs (men >8.0, women >6.5). Baseline prevalence of participants above these cut points was similar for all intervention groups (P > 0.50) and ranged from 11.9% (>100% age predicted) to 55.1% (>85% age predicted). Baseline prevalence and age-, sex-, and race/ethnic group–adjusted percentage of participants above each cut point increased significantly after AT and ATRT (P < 0.05 for all). Structured exercise training, especially the AT component, was associated with a greater number of participants moving above established cut points indicative of low CRF. These results have public health and clinical implications for the growing number of patients with type 2 diabetes at high risk for CVD.
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DOI：
10.1016/0735-1097(93)90832-l
发表时间：
1993-07-01
影响因子：
24
作者：
MORRIS, CK;MYERS, J;HIDEG, A
通讯作者：
HIDEG, A
影响因子：
39.2
作者：
Wei, M;Gibbons, LW;Blair, SN
通讯作者：
Blair, SN
影响因子：
37.8
作者：
Gulati, M;Pandey, DK;Black, HR
通讯作者：
Black, HR
影响因子：
24
作者：
Artero, Enrique G.;Lee, Duck-chul;Ruiz, Jonatan R.;Sui, Xuemei;Ortega, Francisco B.;Church, Timothy S.;Lavie, Carl J.;Castillo, Manuel J.;Blair, Steven N.
通讯作者：
Blair, Steven N.
影响因子：
39.2
作者：
Sigal, Ronald J.;Kenny, Glen P.;Jaffey, James
通讯作者：
Jaffey, James