Altered cortical activation in adolescents with acute migraine: a magnetoencephalography study.
Altered cortical activation in adolescents with acute migraine: a magnetoencephalography study.
复制标题
DOI：
10.1016/j.jpain.2013.04.009
复制
发表时间：
2013-12
期刊：
影响因子：
4
通讯作者：
Hershey, Andrew D.
中科院分区：
文献类型：
--
作者：
Xiang, Jing;deGrauw, Xinyao;Korostenskaja, Milena;Korman, Abraham M.;O'Brien, Hope L.;Kabbouche, Marielle A.;Powers, Scott W.;Hershey, Andrew D.
为了定量评估儿童偏头痛的皮质功能障碍，使用脑磁图（MEG）系统以6，000 Hz的采样率对31名患有急性偏头痛的青少年和年龄和性别匹配的对照进行了研究。神经磁脑激活是由手指敲击任务引起的。使用Morlet小波和波束形成器分析5至2，884 Hz的脑磁图数据的频谱和空间特征。与对照组相比，31名偏头痛受试者在头痛发作期（发作期）表现出5至30 Hz的神经磁激活显著延长，100至200 Hz的频谱功率增加，辅助运动区（枕叶和同侧感觉运动皮质）在2，200至2，800 Hz的神经磁激活可能性更高。在31名偏头痛受试者中，16名偏头痛受试者在其头痛缓解期（发作间期）显示，除了发作间期100至200 Hz的频谱功率显著降低外，发作间期和对照组MEG数据之间无显著差异。结果表明，偏头痛受试者有显着异常的发作期脑激活，这可以正常化间歇。由运动引发的低频和高频范围内的异常发作脑激活的传播可能在偏头痛发作的级联中起关键作用。这是第一项研究，重点是使用5至2，884 Hz频率范围内的MEG信号对偏头痛青少年皮质功能障碍的频谱和空间特征进行研究。这种分析异常的大脑激活可能对未来开发新的偏头痛治疗干预措施很重要。
To quantitatively assess cortical dysfunction in pediatric migraine, 31 adolescents with acute migraine and age- and gender-matched controls were studied using a magnetoencephalography (MEG) system at a sampling rate of 6,000 Hz. Neuromagnetic brain activation was elicited by a finger-tapping task. The spectral and spatial signatures of magnetoencephalography data in 5 to 2,884 Hz were analyzed using Morlet wavelet and beamformers. Compared with controls, 31 migraine subjects during their headache attack phases (ictal) showed significantly prolonged latencies of neuromagnetic activation in 5 to 30 Hz, increased spectral power in 100 to 200 Hz, and a higher likelihood of neuromagnetic activation in the supplementary motor area, the occipital and ipsilateral sensorimotor cortices, in 2,200 to 2,800 Hz. Of the 31 migraine subjects, 16 migraine subjects during their headache-free phases (interictal) showed that there were no significant differences between interictal and control MEG data except that interictal spectral power in 100 to 200 Hz was significantly decreased. The results demonstrated that migraine subjects had significantly aberrant ictal brain activation, which can normalize interictally. The spread of abnormal ictal brain activation in both low- and high-frequency ranges triggered by movements may play a key role in the cascade of migraine attacks. This is the first study focusing on the spectral and spatial signatures of cortical dysfunction in adolescents with migraine using MEG signals in a frequency range of 5 to 2,884 Hz. This analyzing aberrant brain activation may be important for developing new therapeutic interventions for migraine in the future.
登录
查看更多内容
影响因子：
3
作者：
Kotecha, Rupesh;Xiang, Jing;deGrauw, Ton
通讯作者：
deGrauw, Ton
影响因子：
3.7
作者：
Hershey, Andrew D;Kabbouche, Marielle A;Powers, Scott W
通讯作者：
Powers, Scott W
影响因子：
2.4
作者：
Sakura, Yuji;Terada, Kiyohito;Inoue, Yushi
通讯作者：
Inoue, Yushi
影响因子：
7.4
作者：
Siniatchkin, Michael;Jonas, Anne;Stephani, Ulrich
通讯作者：
Stephani, Ulrich
影响因子：
11.2
作者：
Bowyer, SM;Aurora, SK;Welch, KMA
通讯作者：
Welch, KMA