The relationship of sugar to population-level diabetes prevalence: an econometric analysis of repeated cross-sectional data.
The relationship of sugar to population-level diabetes prevalence: an econometric analysis of repeated cross-sectional data.
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DOI：
10.1371/journal.pone.0057873
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Lustig RH
中科院分区：
文献类型：
--
作者：
Basu S;Yoffe P;Hills N;Lustig RH
虽然实验和观察性研究表明，糖摄入量与2型糖尿病的发展有关，独立于其在肥胖中的作用，但尚不清楚糖摄入量的改变是否可以解释总体人群中糖尿病患病率的差异。利用175个国家关于糖尿病和食物营养成分的重复横截面数据的计量经济模型，我们发现，在测试了潜在的选择偏差并控制了其他食物类型（包括纤维、肉类、水果、油、谷物）、总热量、超重和肥胖、时期效应、饮食习惯、饮食习惯、饮食习惯和饮食习惯等因素后，每增加150千卡/人/天的糖供应（约一罐苏打水/天），糖尿病患病率就会增加1.1% （p <0.001）。以及一些社会经济变量，如老龄化、城市化和收入。在控制肥胖和其他混杂因素后，没有其他食物类型与糖尿病患病率产生显著的个体关联。糖对糖尿病的影响与久坐行为和饮酒无关，这种影响会受到肥胖或超重的影响，但不会受到影响。糖暴露的持续时间和程度以剂量依赖的方式与糖尿病患病率显著相关，而糖暴露的减少与随后糖尿病发病率的显著下降相关，独立于其他社会经济、饮食和肥胖患病率的变化。可得糖量的差异在统计上解释了人群水平上糖尿病患病率的变化，而这些变化不能用体育活动、超重或肥胖来解释。
While experimental and observational studies suggest that sugar intake is associated with the development of type 2 diabetes, independent of its role in obesity, it is unclear whether alterations in sugar intake can account for differences in diabetes prevalence among overall populations. Using econometric models of repeated cross-sectional data on diabetes and nutritional components of food from 175 countries, we found that every 150 kcal/person/day increase in sugar availability (about one can of soda/day) was associated with increased diabetes prevalence by 1.1% (p <0.001) after testing for potential selection biases and controlling for other food types (including fibers, meats, fruits, oils, cereals), total calories, overweight and obesity, period-effects, and several socioeconomic variables such as aging, urbanization and income. No other food types yielded significant individual associations with diabetes prevalence after controlling for obesity and other confounders. The impact of sugar on diabetes was independent of sedentary behavior and alcohol use, and the effect was modified but not confounded by obesity or overweight. Duration and degree of sugar exposure correlated significantly with diabetes prevalence in a dose-dependent manner, while declines in sugar exposure correlated with significant subsequent declines in diabetes rates independently of other socioeconomic, dietary and obesity prevalence changes. Differences in sugar availability statistically explain variations in diabetes prevalence rates at a population level that are not explained by physical activity, overweight or obesity.
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DOI：
10.1111/j.1752-8062.2011.00298.x
发表时间：
2011-08
期刊：
Clinical and translational science
影响因子：
--
作者：
Bremer AA;Stanhope KL;Graham JL;Cummings BP;Wang W;Saville BR;Havel PJ
通讯作者：
Havel PJ
影响因子：
3.4
作者：
Elobeld, Amani;Beghin, John
通讯作者：
Beghin, John
影响因子：
7.7
作者：
Abbasi, F;Chu, JW;Reaven, PD
通讯作者：
Reaven, PD
影响因子：
6.1
作者：
HAUSMAN, JA
通讯作者：
HAUSMAN, JA
影响因子：
3.7
作者：
Hall KD;Guo J;Dore M;Chow CC
通讯作者：
Chow CC