The Nature of Immune Responses to Influenza Vaccination in High-Risk Populations.
The Nature of Immune Responses to Influenza Vaccination in High-Risk Populations.
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DOI：
10.3390/v13061109
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发表时间：
2021-06-09
期刊：
影响因子：
--
通讯作者：
Schultz-Cherry S
中科院分区：
文献类型：
--
作者：
Wiggins KB;Smith MA;Schultz-Cherry S
目前的大流行使人们重新认识到疫苗对促进个人和公共健康的至关重要性。流感疫苗一直是我们控制感染的主要工具，以预防季节性流行病和大流行病，如2009年H1N1甲型流感病毒大流行。某些高风险人群，包括老年人、肥胖症患者和患有2型糖尿病等合并症的个体，更容易受到疾病严重程度增加和疫苗有效性降低的影响。高风险人群具有独特的微环境和免疫反应，导致流感感染的脆弱性增加。这篇综述的重点是这些差异，因为我们调查流感疫苗接种的免疫反应的变化。为了开发更好的流感疫苗，了解如何改善我们不断增长的高危人群的反应至关重要。
The current pandemic has brought a renewed appreciation for the critical importance of vaccines for the promotion of both individual and public health. Influenza vaccines have been our primary tool for infection control to prevent seasonal epidemics and pandemics such as the 2009 H1N1 influenza A virus pandemic. Certain high-risk populations, including the elderly, people with obesity, and individuals with comorbidities such as type 2 diabetes mellitus, are more susceptible to increased disease severity and decreased vaccine efficacy. High-risk populations have unique microenvironments and immune responses that contribute to increased vulnerability for influenza infections. This review focuses on these differences as we investigate the variations in immune responses to influenza vaccination. In order to develop better influenza vaccines, it is critical to understand how to improve responses in our ever-growing high-risk populations.
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影响因子：
16.2
作者：
Allard R;Leclerc P;Tremblay C;Tannenbaum TN
通讯作者：
Tannenbaum TN
影响因子：
4.6
作者：
Fernández-Riejos P;Najib S;Santos-Alvarez J;Martín-Romero C;Pérez-Pérez A;González-Yanes C;Sánchez-Margalet V
通讯作者：
Sánchez-Margalet V
DOI：
10.4049/jimmunol.1600820
发表时间：
2016-11-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Cho KW;Zamarron BF;Muir LA;Singer K;Porsche CE;DelProposto JB;Geletka L;Meyer KA;O'Rourke RW;Lumeng CN
通讯作者：
Lumeng CN
影响因子：
3.5
作者：
Eliakim, A;Swindt, C;Cooper, DM
通讯作者：
Cooper, DM
影响因子：
9.3
作者：
Caballero, Benjamin
通讯作者：
Caballero, Benjamin