State-based functional connectivity changes associate with cognitive decline in amnestic mild cognitive impairment subjects
State-based functional connectivity changes associate with cognitive decline in amnestic mild cognitive impairment subjects
复制标题
基于状态的功能连接变化与遗忘性轻度认知障碍受试者的认知下降相关
DOI：
10.1016/j.bbr.2015.04.013
复制
发表时间：
2015-07
期刊：
影响因子：
--
通讯作者：
Zhang Zhijun
中科院分区：
文献类型：
--
作者：
Shi Yongmei;Yu Hui;Xie Chunming;Zhang Zhijun
情景记忆(EM)功能障碍是遗忘性轻度认知障碍(AMCI)患者的一个主要特征，并具有转化为阿尔茨海默病(AD)的高风险。然而，当一种情况被切换时，EM网络如何被调制是未知的。26名AMCI和22名认知正常(CN)受试者参加了这项研究。所有受试者都完成了多维神经心理学测试，并在静息状态和情景记忆提取任务状态下接受了功能磁共振成像扫描。EM网络是使用基于种子的功能连接性(FC)方法构建的。AMCI受试者在情景记忆和执行功能方面的认知表现较差。结果显示，与CN组相比，aMCI组左侧后海马旁回(LpPHG)与左侧腹侧前额叶内侧皮质和右侧中央后回(RPCG)的连接性显著降低。同时，在从静息状态转变为任务状态的所有受试者中，LpPHG与右侧背内侧前额叶(RDMPFC)、RPCG、左下顶叶和双侧顶上叶的连接增加。有趣的是，在aMCI受试者中，LpPHG-RDMPFC连接强度的变化与EM评分和执行功能显著相关。结果，一般脑区在功能上被组织并整合到EM网络中，这有力地表明了更多的认知资源被动员起来，以满足任务状态下的认知需求的挑战。这些发现扩展了我们对非MCI受试者EM缺陷的潜在机制的理解。
Episodic memory (EM) dysfunction is a central characteristic of amnestic mild cognitive impairment (aMCI) subjects, and has a high risk of converting to Alzheimer's disease (AD). However, it is unknown how the EM network is modulated when a situation is switched. Twenty-six aMCI and twenty-two cognitively normal (CN) subjects were enrolled in this study. All of the subjects completed multi-dimensional neuropsychological tests and underwent functional magnetic resonance imaging scans during a resting-state and an episodic memory retrieval task state. The EM network was constructed using a seed-based functional connectivity (FC) approach. AMCI subjects showed poorer cognitive performances in the episodic memory and executive function. We demonstrated that connectivity of the left posterior parahippocampal gyrus (LpPHG) connected to the left ventral medial prefrontal cortex and the right postcentral gyrus (RPCG) was significantly decreased in aMCI subjects compared to CN subjects. Meanwhile, there was increased connectivity of the LpPHG to the right dorsal medial prefrontal cortex (RDMPFC), RPCG, left inferior parietal cortex, and bilateral superior parietal lobe in all of the subjects that changed from a resting-state to a task-state. Interestingly, the changed LpPHG-RDMPFC connectivity strength was significantly correlated with EM scores and executive function in the aMCI subjects. As a result, general brain regions are functionally organized and integrated into the EM network, and this strongly suggests that more cognitive resources are mobilized to meet the challenge of cognitive demand in the task state. These findings extend our understanding of the underlying mechanisms of EM deficits in aMCI subjects.
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DOI：
10.1523/jneurosci.3777-14.2015
发表时间：
2015-01
期刊：
The Journal of Neuroscience
影响因子：
--
作者：
J. Yau;G. McNally
通讯作者：
J. Yau;G. McNally
影响因子：
5.7
作者：
Baldassano, Christopher;Beck, Diane M.;Fei-Fei, Li
通讯作者：
Fei-Fei, Li
DOI：
--
发表时间：
--
期刊：
--
影响因子：
--
作者：
M. Rugg;Kaia L. Vilberg;Steve Petersen;Wolf Singer
通讯作者：
M. Rugg;Kaia L. Vilberg;Steve Petersen;Wolf Singer
影响因子：
16.2
作者：
Dobbins, IG;Foley, H;Wagner, AD
通讯作者：
Wagner, AD
影响因子：
4.4
作者：
Goveas, Joseph S.;Xie, Chunming;Ward, B. Douglas;Wu, Zhilin;Li, Wenjun;Franczak, Malgorzata;Jones, Jennifer L.;Antuono, Piero G.;Li, Shi-Jiang
通讯作者：
Li, Shi-Jiang