Spire, an actin nucleation factor, regulates cell division during Drosophila heart development.
Spire, an actin nucleation factor, regulates cell division during Drosophila heart development.
复制标题
DOI：
10.1371/journal.pone.0030565
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Schulz RA
中科院分区：
文献类型：
--
作者：
Xu P;Johnson TL;Stoller-Conrad JR;Schulz RA
The Drosophila dorsal vessel is a beneficial model system for studying the regulation of early heart development. Spire (Spir), an actin-nucleation factor, regulates actin dynamics in many developmental processes, such as cell shape determination, intracellular transport, and locomotion. Through protein expression pattern analysis, we demonstrate that the absence of spir function affects cell division in Myocyte enhancer factor 2-, Tinman (Tin)-, Even-skipped- and Seven up (Svp)-positive heart cells. In addition, genetic interaction analysis shows that spir functionally interacts with Dorsocross, tin, and pannier to properly specify the cardiac fate. Furthermore, through visualization of double heterozygous embryos, we determines that spir cooperates with CycA for heart cell specification and division. Finally, when comparing the spir mutant phenotype with that of a CycA mutant, the results suggest that most Svp-positive progenitors in spir mutant embryos cannot undergo full cell division at cell cycle 15, and that Tin-positive progenitors are arrested at cell cycle 16 as double-nucleated cells. We conclude that Spir plays a crucial role in controlling dorsal vessel formation and has a function in cell division during heart tube morphogenesis.
登录
查看更多内容
DOI：
10.1083/jcb.200706196
发表时间：
2007-10-08
期刊：
The Journal of cell biology
影响因子：
--
作者：
Quinlan ME;Hilgert S;Bedrossian A;Mullins RD;Kerkhoff E
通讯作者：
Kerkhoff E
影响因子：
56.9
作者：
OFARRELL, PH;EDGAR, BA;LEHNER, CF
通讯作者：
LEHNER, CF
影响因子：
10.5
作者：
AZPIAZU, N;FRASCH, M
通讯作者：
FRASCH, M
影响因子：
4.6
作者：
Alvarez, AD;Shi, WY;Skeath, JB
通讯作者：
Skeath, JB
影响因子：
11.4
作者：
KNOBLICH, JA;LEHNER, CF
通讯作者：
LEHNER, CF