Matrix metalloproteinase levels in early HIV infection and relation to in vivo brain status.
Matrix metalloproteinase levels in early HIV infection and relation to in vivo brain status.
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DOI：
10.1007/s13365-013-0197-3
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发表时间：
2013-10
影响因子：
3.2
通讯作者：
Ragin, Ann B.
中科院分区：
文献类型：
--
作者：
Li, Suyang;Wu, Ying;Keating, Sheila M.;Du, Hongyan;Sammet, Christina L.;Zadikoff, Cindy;Mahadevia, Riti;Epstein, Leon G.;Ragin, Ann B.
关键词：
基质金属蛋白酶(MMPs)已被认为与HIV相关的神经损伤有关；然而，这种关系在感染早期还没有被研究过。使用Luminex技术对芝加哥早期HIV感染研究中52名HIV感染者和21名血清阴性参与者的血浆基质金属蛋白酶-1、-2、-7、-9和-10水平进行了比较。根据抗体反应性、病毒血症和抗逆转录病毒状态定义的HIV亚组以及可用的脑脊液样本(n=9)中也检测了基质金属蛋白酶水平。评估MMPs与认知功能的关系模式，以及体内脑部的定量磁共振测量。血浆基质金属蛋白酶-2水平在HIV感染早期显著降低，并与脑白质完整性改变和脑萎缩改变相关。治疗后的HIV亚组患者血清中的MMP9水平明显高于单纯HIV亚组。脑脊液中仅检测到基质金属蛋白酶-2和-9，脑脊液基质金属蛋白酶-2与脑白质完整性和基底节体积变化相关。与认知功能的关系也被识别出来。血浆和脑脊液中的基质金属蛋白酶-2水平与脑结构和功能的早期变化相对应。这些发现建立了MMPs和以前未被发现的早期HIV感染的神经状态之间的联系。
Matrix metalloproteinases (MMPs) have been implicated in HIV associated neurological injury; however, this relationship has not been studied early in infection. Plasma levels of MMP-1, -2, -7, -9, and -10 measured using Luminex technology were compared in 52 HIV and 21 seronegative participants of the Chicago Early HIV Infection study. MMP levels were also examined in HIV subgroups defined by antibody reactivity, viremia, and antiretroviral status, as well as in available CSF samples (n=9). MMPs were evaluated for patterns of relationship to cognitive function and to quantitative magnetic resonance measurements of the brain derived in vivo. Plasma MMP-2 levels were significantly reduced in early HIV infection and correlated with altered white matter integrity and atrophic brain changes. MMP-9 levels were higher in the treated than naïve HIV subgroup. Only MMP-2 and -9 were detected in CSF; CSF MMP-2 correlated with white matter integrity and with volumetric changes in basal ganglia. Relationships with cognitive function were also identified. MMP-2 levels in plasma and in CSF correspond to early changes in brain structure and function. These findings establish a link between MMPs and neurological status previously unidentified in early HIV infection.
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影响因子：
3.2
作者：
Becker, James T.;Sanders, Joanne;Madsen, Sarah K.;Ragin, Ann;Kingsley, Lawrence;Maruca, Victoria;Cohen, Bruce;Goodkin, Karl;Martin, Eileen;Miller, Eric N.;Sacktor, Ned;Alger, Jeffery R.;Barker, Peter B.;Saharan, Priyanka;Carmichael, Owen T.;Thompson, Paul M.
通讯作者：
Thompson, Paul M.
影响因子：
4.4
作者：
CHIODI, F;SONNERBORG, A;FENYO, EM
通讯作者：
FENYO, EM
影响因子：
5.4
作者：
Ghorpade, A;Persidskaia, R;Gendelman, HE
通讯作者：
Gendelman, HE
影响因子：
4
作者：
Lim, Nastasia K-H;Villemagne, Victor L.;Li, Qiao-Xin
通讯作者：
Li, Qiao-Xin
影响因子：
12.7
作者：
Buttner, A;Mehraein, P;Weis, S
通讯作者：
Weis, S