5-HT, prefrontal function and aging: fMRI of inhibition and acute tryptophan depletion
5-HT, prefrontal function and aging: fMRI of inhibition and acute tryptophan depletion
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5-HT、前额叶功能和衰老：抑制和急性色氨酸消耗的功能磁共振成像
DOI：
10.1016/j.neurobiolaging.2007.09.013
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发表时间：
2009
影响因子：
4.2
通讯作者：
D. Murphy
中科院分区：
文献类型：
--
作者：
M. Lamar;W. Cutter;K. Rubia;M. Brammer;E. Daly;M. Craig;A. Cleare;D. Murphy
与年龄相关的前额叶功能下降和与年龄相关的前额叶血清素（5-HT）下降有文献记载。5-HT对前额皮质（PFC）的影响也有文献记载；然而，没有人研究过实验性5-羟色胺调节对健康老年人PFC的影响。我们利用功能磁共振成像和急性色氨酸耗损（ATD）研究了5-羟色胺对认知干扰抑制（Simon任务）期间10名55岁以上女性（平均=63.0±5.3岁）脑功能的影响。ATD不影响任务绩效；它确实影响了大脑功能。在假耗竭或无耗竭期间，参与者激活了与Simon相关的大脑区域（如左下PFC）。在ATD期间，没有前额叶，但有后脑交替激活。与假手术相比，ATD降低了左下PFC、前扣带和基底节区的活动，但增加了新小脑和顶叶的活动。在老年人中，ATD调节与认知干扰抑制相关的任务脑激活，并与前向后的激活转移有关。在ATD期间，通过增加小脑和顶叶的贡献来弥补额扣带纹状体参与的减少，从而维持Simon的成功表现。
Age-related declines in prefrontal functions and age-related declines in prefrontal serotonin (5-HT) are documented. The effect of 5-HT on prefrontal cortex (PFC) is also documented; however, no one has examined the effect of experimental 5-HT modulation on PFC in healthy older adults. We investigated the effect of 5-HT on brain functioning in 10 women over 55 (mean=63.0±5.3 years) during cognitive interference inhibition (Simon task) using fMRI and acute tryptophan depletion (ATD). ATD did not affect task performance; it did affect brain function. During sham/no depletion, participants activated brain regions associated with the Simon (e.g., left inferior PFC). During ATD, there was no prefrontal but alternative posterior brain activation. ATD relative to sham reduced activity in left inferior PFC, anterior cingulate and basal ganglia but increased activity within neocerebellum and parietal lobe. In older adults, ATD modulates task-relevant brain activation for cognitive interference inhibition and is associated with an anterior-to-posterior activation shift. Maintaining successful Simon performance during ATD is achieved by increasing cerebellar and parietal contributions to compensate for decreased fronto-cingulo-striatal involvement.
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影响因子：
--
作者：
MORECRAFT, RJ;GEULA, C;MESULAM, MM
通讯作者：
MESULAM, MM
影响因子：
5.9
作者：
BECK, AT;BROWN, G;STEER, RA
通讯作者：
STEER, RA
影响因子：
56.9
作者：
MIDDLETON, FA;STRICK, PL
通讯作者：
STRICK, PL
DOI：
10.1073/pnas.94.10.5308
发表时间：
1997-05-13
影响因子：
11.1
作者：
Nishizawa, S;Benkelfat, C;Diksic, M
通讯作者：
Diksic, M