Metabolism of Dendritic Cells in Tumor Microenvironment: For Immunotherapy.
Metabolism of Dendritic Cells in Tumor Microenvironment: For Immunotherapy.
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肿瘤微环境中树突状细胞的代谢：用于免疫治疗
DOI：
10.3389/fimmu.2021.613492
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发表时间：
2021
影响因子：
7.3
通讯作者：
Liu S
中科院分区：
文献类型：
--
作者：
Peng X;He Y;Huang J;Tao Y;Liu S
树突状细胞（DCs）是一类抗原呈递细胞，其职责是捕获来自病原体或肿瘤的抗原，并将其呈递给T细胞以引发免疫反应。DCs的代谢过程控制着其发育、极化和成熟进程，并为其功能提供能量支持。然而，在肿瘤微环境（TME）中，DCs的免疫活性通常受到抑制。肿瘤细胞的代谢异常会导致TME中的代谢变化，如糖酵解增强、乳酸和脂质积累、酸化、色氨酸缺乏等，这些变化限制了DCs的功能，进而导致肿瘤免疫逃逸的发生。将代谢调节与免疫治疗相结合，能够增强DCs的抗原呈递能力和T细胞激活能力，改善现有的抗肿瘤治疗效果，并克服现阶段DC相关疗法的缺陷，在肿瘤治疗中具有巨大潜力。因此，我们综述了DCs的葡萄糖、脂质和氨基酸代谢，以及受TME影响后的代谢变化。结合DCs潜在的代谢靶点，总结了可能的抗肿瘤治疗途径。
Dendritic cells (DCs) are a type of an antigen-presenting cell which undertake a job on capturing antigens coming from pathogens or tumors and presenting to T cells for immune response. The metabolism of DCs controls its development, polarization, and maturation processes and provides energy support for its functions. However, the immune activity of DCs in tumor microenvironment (TME) is inhibited generally. Abnormal metabolism of tumor cells causes metabolic changes in TME, such as hyperglycolysis, lactate and lipid accumulation, acidification, tryptophan deprivation, which limit the function of DCs and lead to the occurrence of tumor immune escape. Combined metabolic regulation with immunotherapy can strengthen the ability of antigen-presentation and T cell activation of DCs, improve the existing anti-tumor therapy, and overcome the defects of DC-related therapies in the current stage, which has great potential in oncology therapy. Therefore, we reviewed the glucose, lipid, and amino acid metabolism of DCs, as well as the metabolic changes after being affected by TME. Together with the potential metabolic targets of DCs, possible anti-tumor therapeutic pathways were summarized.
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影响因子：
11.5
作者：
Bol, Kalijn F.;Schreibelt, Gerty;Figdor, Carl G.
通讯作者：
Figdor, Carl G.
影响因子：
6.4
作者：
Collin M;Bigley V
通讯作者：
Bigley V
影响因子：
64.5
作者：
Cubillos-Ruiz JR;Silberman PC;Rutkowski MR;Chopra S;Perales-Puchalt A;Song M;Zhang S;Bettigole SE;Gupta D;Holcomb K;Ellenson LH;Caputo T;Lee AH;Conejo-Garcia JR;Glimcher LH
通讯作者：
Glimcher LH
影响因子：
7.3
作者：
Albini A;Bruno A;Noonan DM;Mortara L
通讯作者：
Mortara L
DOI：
10.1186/s40880-018-0301-4
发表时间：
2018-05-21
期刊：
Cancer communications (London, England)
影响因子：
--
作者：
Cheng C;Geng F;Cheng X;Guo D
通讯作者：
Guo D