The Rising Burden of Inflammatory Bowel Disease in Denmark Over Two Decades: A Nationwide Cohort Study.
The Rising Burden of Inflammatory Bowel Disease in Denmark Over Two Decades: A Nationwide Cohort Study.
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DOI：
10.1053/j.gastro.2022.07.062
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发表时间：
2022-12
期刊：
影响因子：
29.4
通讯作者：
中科院分区：
文献类型：
--
作者：
炎症性肠病（IBD）流行病学分期的变化对了解IBD病因和管理临床护理具有重要意义。我们对1995年至2016年丹麦全国队列IBD流行病学进行了时间分析。我们使用丹麦登记册获取1995年至2016年期间ibd相关门诊和住院患者接触的人口统计数据。IBD诊断定义为在两年内有≥2例克罗恩病（CD）或溃疡性结肠炎（UC）相关登记。我们根据年龄和性别对CD和UC的总体和年发病率和患病率进行了标准化估计。共有47,830人符合IBD诊断标准，其中诊断为CD和UC的分别为33%和67%。在1995年至2016年期间，每10万人年的发病率（95%置信区间）从CD的9.1（8.3,10.0）上升到17.8 (16.8,19.0)，UC的发病率从21.0（19.8,22.3）上升到28.4（27.0,29.8）。CD和UC发病率的最高增幅分别发生在儿童和年轻人中。1995年至2016年，IBD患病率翻了一番；UC患病率在40岁至40岁人群中增幅最大（2.5倍）。在此期间，IBD人群的中位年龄增加了6-7岁。在丹麦，IBD的发病率和流行率在过去二十年中有所增加。IBD人群正在向老年化转变。这些发现对理解环境变化以及为老年IBD人群准备医疗保健系统具有重要意义。通过对丹麦全国范围内的数据进行20多年的随访，我们发现IBD的发病率和流行率正在增加，IBD人群正在向老年化转变。
Shifts in epidemiological stages of inflammatory bowel disease (IBD) carry implications towards understanding IBD etiology and managing clinical care. We conducted a temporal analysis of the epidemiology of IBD between 1995 and 2016 in the Danish nationwide cohort. We used the Danish registers to obtain data on demographics and IBD-related outpatient and inpatient contacts between 1995 and 2016. IBD diagnosis was defined as having ≥2 Crohn’s disease (CD)- or ulcerative colitis (UC)-related registrations within a two-year period. We estimated overall and annual incidence rates and prevalence of CD and UC standardized with respect to age and sex. A total of 47,830 individuals met the criteria for IBD diagnosis, of which 33% and 67% were diagnosed with CD and UC, respectively. Between 1995 and 2016, the incidence rate (95% confidence interval) per 100,000 person years rose from 9.1 (8.3, 10.0) to 17.8 (16.8, 19.0) for CD, and from 21.0 (19.8, 22.3) to 28.4 (27.0, 29.8) for UC. The highest increase in CD and UC incidence rates occurred in children and young adults, respectively. The prevalence of IBD doubled from 1995 to 2016; the greatest increase (2.5-fold) was in UC prevalence among individuals >40 years of age. During this period, the median age of the IBD population increased by 6–7 years. In Denmark, the incidence and prevalence of IBD have increased over the last two decades. The IBD population is shifting towards an older age. These findings have implications towards understanding environmental shifts as well as preparing healthcare systems for an aging IBD population. Using Danish nationwide data with follow up over two decades, we report that IBD incidence and prevalence are increasing and that the IBD population is shifting towards an older age.
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DOI：
10.1038/s41575-020-00360-x
发表时间：
2021-01
期刊：
Nature reviews. Gastroenterology & hepatology
影响因子：
--
作者：
Kaplan GG;Windsor JW
通讯作者：
Windsor JW
影响因子：
3.6
作者：
Kochar B;Ufere NN;Ritchie CS;Lai JC
通讯作者：
Lai JC
DOI：
10.1097/00042737-200606000-00005
发表时间：
2006-06-01
影响因子：
2.1
作者：
Jacobsen, Bent A.;Fallingborg, Jan;Sorensen, Henrik T.
通讯作者：
Sorensen, Henrik T.
影响因子：
8
作者：
Norgard, Bente Mertz;Nielsen, Jan;Qvist, Niels
通讯作者：
Qvist, Niels
影响因子：
7.6
作者：
Forss, Anders;Clements, Mark;Ludvigsson, Jonas F.
通讯作者：
Ludvigsson, Jonas F.