Association of BMI trajectories with cardiometabolic risk among low-income Mexican American children.
Association of BMI trajectories with cardiometabolic risk among low-income Mexican American children.
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DOI：
10.1038/s41390-022-02250-1
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发表时间：
2023-04
影响因子：
3.6
通讯作者：
Luecken, Linda J.
中科院分区：
文献类型：
--
作者：
Perez, Marisol;Winstone, Laura K.;Hernandez, Juan C.;Curci, Sarah G.;McNeish, Daniel;Luecken, Linda J.
本研究的目的是确定 2 至 7.5 岁期间 BMI 增长的不同轨迹，并在低收入墨西哥裔美国儿童样本中检查其与 7.5 岁时心脏代谢风险标志物的关联。这项纵向队列研究招募了 322 名母婴二人在产前和 2、3、4.5、6 和 7.5 岁时参与。在每个时间点评估儿童身高/体重、腰围和血压。在 7.5 岁时从儿童身上采集血液。根据出生体重的共变，确定了三种 BMI 轨迹：低稳定 BMI（样本的 73%）、高稳定 BMI（样本的 5.6%）和随时间增加的 BMI（样本的 21.4%）。高稳定和增加的 BMI 类别比低稳定 BMI 类别具有更高的腰围和收缩压以及更低的 HDL-c (ps < 0.05)。在 BMI 低于 85% 的儿童中，16% 的儿童具有三个或以上心脏代谢风险指标。 BMI 类别与现有文献一致。对于年轻人来说，标准的医疗实践是在 BMI 高时检查心脏代谢风险指标；然而，这种做法会漏掉我们样本中 16% 的年轻人，他们表现出心脏代谢风险，但没有根据 BMI 进行筛查。研究表明，与其他族裔群体相比，墨西哥裔美国青年面临心脏代谢失调的风险，但纵向研究却很少。与低稳定 BMI 类别相比，增加的 BMI 和高稳定 BMI 类别与较大的腰围、较高的收缩压和较低的 HDL 胆固醇相关。儿童时期的体重指数轨迹可预测心脏代谢风险指标。作为决定何时测试心脏代谢指标的唯一筛查指标，仅凭体重指数就会漏掉一些表现出心脏代谢失调的儿童。
The aim of this study was to identify distinct trajectories of BMI growth from 2 to 7.5 years and examine their associations with markers of cardiometabolic risk at age 7.5 years among a sample of low-income Mexican American children. This longitudinal cohort study recruited 322 mother–child dyads to participate prenatally and at child age 2, 3, 4.5, 6, and 7.5 years. Child height/weight, waist circumference, and blood pressure were assessed at each time point. Blood was collected from child at 7.5 years. Covarying for birthweight, three BMI trajectories were identified: Low-Stable BMI (73% of the sample), High-Stable BMI (5.6% of the sample), and Increasing BMI over time (21.4% of the sample). The High-Stable and Increasing BMI classes had higher waist circumference and systolic blood pressure and lower HDL-c than the Low-Stable BMI class (ps < 0.05). Among children with BMIs below the 85th percentile, 16% had three or more cardiometabolic risk indicators. BMI classes were consistent with existing literature. For youth, standard medical practice is to examine cardiometabolic risk indicators when BMI is high; however, this practice would miss 16% of youth in our sample who exhibit cardiometabolic risk but do not screen in based on BMI. Research indicates Mexican American youth are at risk for cardiometabolic dysregulation relative to other ethnic groups, yet there is a paucity of longitudinal research. An Increasing BMI and a High-Stable BMI class were associated with larger waist circumference, higher systolic blood pressure, and lower HDL cholesterol than the Low-Stable BMI class. BMI trajectories in childhood predict cardiometabolic risk indicators. As the sole screener for deciding when to test cardiometabolic indicators, BMI alone will miss some children exhibiting cardiometabolic dysregulation.
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作者：
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通讯作者：
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10.1001/archpediatrics.2009.3
发表时间：
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