Dietary fiber intake and mortality in the NIH-AARP diet and health study.
Dietary fiber intake and mortality in the NIH-AARP diet and health study.
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DOI：
10.1001/archinternmed.2011.18
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发表时间：
2011-06-27
影响因子：
--
通讯作者：
Schatzkin, Arthur
中科院分区：
文献类型：
--
作者：
Park, Yikyung;Subar, Amy F.;Hollenbeck, Albert;Schatzkin, Arthur
膳食纤维被认为可以降低患冠心病、糖尿病和某些癌症的风险。然而，人们对膳食纤维对总死亡和特定原因死亡的影响知之甚少。我们在NIH-AARP饮食与健康研究（一项前瞻性队列研究）中检查了膳食纤维摄入量与总死亡率和特定原因死亡率的关系。在基线时使用食物频率问卷评估饮食。使用国家死亡指数Plus确定死亡原因。使用考克斯比例风险模型估计相对风险（RR）和双侧95%置信区间（CI）。在平均9年的随访中，我们确定了20,126例男性死亡和11,330例女性死亡。膳食纤维摄入量与男性和女性总死亡风险显着降低相关（比较最高与最低五分位数的多变量RR =0.78，95%CI：0.73-0.82，p趋势，男性<0.001; 0.78。95% CI：0.73-0.85，p趋势，女性<0.001）。膳食纤维摄入量还降低了心血管，传染病和呼吸系统疾病的死亡风险，男性为24%-56%，女性为34%-59%。膳食纤维摄入量和癌症死亡之间的负相关在男性中观察到，但在女性中没有观察到。来自谷物的膳食纤维，而不是来自其他来源的膳食纤维，与男性和女性的总死亡率和死因特异性死亡率呈显著负相关。膳食纤维可以降低心血管、传染病和呼吸道疾病的死亡风险。更多地选择富含纤维的食物可能会带来显着的健康益处。
Dietary fiber has been hypothesized to lower risk of coronary heart disease, diabetes, and some cancers. However, little is known of the effect of dietary fiber on total death and cause-specific deaths. We examined dietary fiber intake in relation to total mortality and death from specific causes in the NIH-AARP Diet and Health Study, a prospective cohort study. Diet was assessed using a food frequency questionnaire at baseline. Cause of death was identified using the National Death Index Plus. Cox proportional hazard models were used to estimate relative risks (RRs) and two-sided 95% confidence intervals (CI). During an average of 9 years of follow-up, we identified 20,126 deaths in men and 11,330 deaths in women. Dietary fiber intake was associated with significantly lowered risk of total death in both men and women (multivariate RR comparing the highest vs. the lowest quintile =0.78, 95% CI:0.73–0.82, p-trend, <0.001 in men; 0.78. 95% CI:0.73–0.85, p-trend, <0.001 in women). Dietary fiber intake also lowered risk of death from cardiovascular, infectious, and respiratory diseases by 24%–56% in men and 34%–59% in women. Inverse association between dietary fiber intake and cancer death was observed in men, but not in women. Dietary fiber from grains, but not from other sources, was significantly inversely related to total and cause-specific death in both men and women. Dietary fiber may reduce the risk of death from cardiovascular, infectious and respiratory diseases. Making fiber-rich food choices more often may provide significant health benefits.
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影响因子：
5
作者：
Aldoori, WH;Giovannucci, EL;Willett, WC
通讯作者：
Willett, WC
影响因子：
5
作者：
ROSNER, B;SPIEGELMAN, D;WILLETT, WC
通讯作者：
WILLETT, WC
影响因子：
--
作者：
Pereira, MA;O'Reilly, E;Ascherio, A
通讯作者：
Ascherio, A
影响因子：
7.1
作者：
Jacobs, David R., Jr.;Andersen, Lene Frost;Blomhoff, Rune
通讯作者：
Blomhoff, Rune
影响因子：
4.2
作者：
Aldoori, WH;Giovannucci, EL;Willett, WC
通讯作者：
Willett, WC