A conceptual model of alcohol use and adherence to antiretroviral therapy: systematic review and theoretical implications for mechanisms of action.

A conceptual model of alcohol use and adherence to antiretroviral therapy: systematic review and theoretical implications for mechanisms of action.
复制标题

酒精使用和遵守抗逆转录病毒疗法的概念模型:对作用机制的系统评价和理论意义。

DOI:
10.1080/17437199.2020.1806722
复制
发表时间:
2022-03
影响因子:
9.8
通讯作者:
Maisto SA
Maisto SA
中科院分区:
心理学1区
文献类型:
--
作者:
Woolf-King SE;Sheinfil AZ;Ramos J;Foley JD;Moskal D;Firkey M;Kellen D;Maisto SA

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饮酒是抗逆转录病毒治疗(ART)依从性的最普遍的相关因素之一,但这种关联的因果过程仍然在很大程度上未被探索。本系统评价的目的是建立一个概念模型,描述饮酒对ART不依从性的因果影响。我们回顾了230项研究,这些研究探讨了饮酒与ART依从性之间的关系,主要目的有三个:(1)复制和扩展先前的文献综述,(2)总结和批评能够回答时间重叠问题的研究设计,(3)总结潜在的作用机制。酒精相关的ART不依从性的模型,提出了指导未来的工作,整合ART依从性的一般理论和酒精中毒的心理和行为影响的理论。概念模型描述了两个机制的过程-前瞻性记忆障碍和互动毒性信念/回避行为-参与酒精相关的有意和无意的不遵守,分别。这个模型可以用来指导未来的研究中经常观察到的酒精消费和遵守之间的相关性的因果过程。
Alcohol consumption is one of the most prevalent correlates of antiretroviral therapy (ART) adherence, yet causal processes underlying this association remain largely unexplored. The goal of this systematic review was to develop a conceptual model that describes the causal effect of alcohol consumption on ART nonadherence. We reviewed 230 studies that examined the association between alcohol consumption and ART adherence with three primary aims: (1) to replicate and extend previous reviews of the literature, (2) to summarize and critique study designs capable of answering questions about temporal overlap and (3) to summarize potential mechanisms of action. A model of alcohol-associated ART nonadherence was proposed to guide future work, integrating general theories of ART adherence and theory on the psychological and behavioral effects of alcohol intoxication. The conceptual model describes two mechanistic processes—prospective memory impairment and interactive toxicity beliefs/avoidance behaviors—involved in alcohol-associated intentional and unintentional nonadherence, respectively. This model can be used to guide future research on the causal processes involved in the frequently observed correlation between alcohol consumption and adherence.
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